This study was carried out during 2017/2018 and 2018/2019 seasons on 5 - year-old Murcott tangerine (Citrus reticulata, Blanco.) planted at 2.5 × 5 meters in sandy soil under drip irrigation system grown under Wady El-Mollak region, Sharkia Governorate, Egypt to evaluate the effect of replacement mineral Nitrogen fertilization using organic and biofertilizers on vegetative growth, yield and leaf mineral content. Trees fertilized with 75% (N) mineral + 25%(N) organic + 150 ml Em1/tree/ year gained the highest values on yield, number of fruits/ tree as well as cropping efficiency, leaf area, nutrients namely N, P, K, Ca and Mg. A great decline in all growth parameters, yield and leaf mineral content were recorded with using inorganic N at 100% N /tree/year or 25% (N) mineral + 75% (N) organic /tree/year either using EM1 nor without EM1. The best results with regard to growth, yield and nutritional status of Murcott tangerine trees were indicated at fertilizing trees with (500 and 600 g) N/tree/year in the first and second seasons, respectively, to increase the age of tree in the second season one, through 75 % inorganic as ammonium nitrate (33.5% N) + 25% organic as chicken manure (3 % N) + 150 ml EM1/ tree /year. Key words: Murcott tangerine, fertilization, organic, biofertilizers, fruit set yield.