Hyperhomocystinemia In Epileptic Patients: the Role of THFR Polymorphism and Antiepileptic Drugs. ارتفاع مستوى الهوموسيستاتين فى مرضى الصرع : دور تعدد نظائر الانزيم المختزل للتراهيدروفوليك والادوية المضاده للصرع

Faculty Medicine Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Nesma Abdel Moneim Mohamed Ghoneim
Journal: inarchternational journal of advanced rese local journal Volume:
Keywords : Hyperhomocystinemia , Epileptic Patients: , Role , THFR Polymorphism    
Abstract:
Hyperhomocystinemia despite can be seen in small perecentage of normal population but associated with increased vascular diseases in epileptics,hyperhomocystinemia in epileptic patients was supposed to develop primarily from a complex interplay between the chronic intake of enzyme inducing AEDs and genetically determined mutations of MTHFR. Ninety two patients with epilepsy between the ages of 18 and 40 years consented to participate in the study in order to study analyses the effect of a C677T polymorphism of MTHFR and AEDs on tHcy levels in patients with epilepsy treated for at least 6 months with monotherapy including the traditional and newer AEDs.
    
     
 
       

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