Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Ameliorative effects of Green Tea Polyphenol Epigallocatechin-3-gallate on chlorpyrifos ovarian toxicity in adult albino rats
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Areeg Amier Kamal Desouky
Staff Zu Site
Abstract In Staff Site
Journal:
Mansoura Journal of Forensic Medicine and Clinical Toxicology Mansoura University; Faculty of Medicine. Department of Forensic Medicine and Toxicology
Volume:
Keywords :
Ameliorative effects , Green , Polyphenol Epigallocatechin-3-gallate , chlorpyrifos
Abstract:
Abstract Chlorpyrifos (CPF) can induce ovarian damage and reproductive dysfunction through oxidative stress mechanisms. These can be reversed by antioxidants such as Epigallocatechin-3-gallate (EGCG) in green tea. This study aimed to investigate the toxicity effects of CPF on rat ovaries and the effectiveness of EGCG to protect against these effects. Fifty adult female albino rats were randomly assigned to five equal groups; negative and positive control groups, EGCG-treated group, CPF treated group and CPF+EGCG-treated group. After four weeks the rat body weight and relative ovarian weight were estimated, and blood samples were collected to assess reproductive hormones (RHs) levels. Evaluation of ovarian oxidative stress indicators malondialdhyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) was performed. Ovarian sections were prepared and examined using the hematoxylin and eosin stain, proliferating cell nuclear antigen, and morphometric study to assess histopathologic changes. CPF treated rats had significant lower body weight and relative ovarian weight compared to controls (P<0.001) and those treated with CPF+EGCG (P<0.001). CPF induced significant reduction in RHs levels and ovarian SOD, GSH and CAT activities when given alone, which were improved by the combined administration of CPF and EGCG. The levels of ovarian MDA and NO were significantly higher in CPF-treated rats than controls and rats treated with CPF+EGCG. The cellular proliferation in ovarian Graafian follicles was significantly suppressed in CPF-treated animals. Hence CPF can induce oxidative damage in rat ovaries, EGCG, a natural potent antioxidant, can be useful against the CPF toxicity effects in ovaries.
Author Related Publications
Areeg Amier Kamal Desouky, "Mesenchymal stem cells enhance AQP1 expression in the sublingual salivary gland of ovariectomized menopausal rat model", Elsevier GmbH, 2021
More
Areeg Amier Kamal Desouky, "Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway", MDPI, 2018
More
Areeg Amier Kamal Desouky, "Hypoxia-Preconditioned Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Mitigate Hypoglycemic Testicular Injury Induced by Insulin in Rats", Karger, 2020
More
Areeg Amier Kamal Desouky, "Mesenchymal stem cells enhance AQP1 expression in the sublingual salivary gland of ovariectomized menopausal rat model", ELSEVIER GMBH, 2021
More
Areeg Amier Kamal Desouky, "Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway", BMC, 2021
More
Department Related Publications
Osama Yassen Ibrahim Mohamed, "تأثيرات التعرض الطويل لجرعات منخفضة من الرصاص علي المخ النامي في الجرذان البيضاء", لايوجد, 1900
More
Osama Yassen Ibrahim Mohamed, "تسمم الشبكية بعد حقن عقار الأنترفيرون ألفا داخل الجسم الزجاجى فى الأرانب: دراسة باستخدام الميكروسكوب الضوئى والألكترونى", لايوجد, 1900
More
Osama Yassen Ibrahim Mohamed, "التغيرات النسيجية و العضيية الدقيقة فى كبد الفأر الأبيض بعد اجراء عملية استئصال جزئى للكبد", لايوجد, 1900
More
Aisha Abdelmoniem Mahmoud Elkhodary, "4. Ghallab, A.M; El- khodary, E.A; Khater, N.A; Barsoum M. Saad Micheal, S.G. (1992): histological and histochemical studies on the effect of alloxan induced diabetes on the skeletal muscles induced of tge rabbit.", لايوجد, 1900
More
Abdelrahman Ahmed Mohamed Elgamal, "Study of chromosome aberrations among workers employed in the wood furniture industry.", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف