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Association between plasma levels of transforming growth factor-beta 1, IL-23 and IL-17 and the severity of autism in Egyptian children
Faculty
Medicine
Year:
2013
Type of Publication:
Article
Pages:
199-204
Authors:
Mohammed, Doaa, Hashim, Haitham, Abdelrahman, Hadeel, Karam, Rehab
DOI:
10.1016/j.rasd.2012.08.007
Journal:
RESEARCH IN AUTISM SPECTRUM DISORDERS ELSEVIER SCI LTD
Volume:
7
Research Area:
Education \& Educational Research; Psychology; Psychiatry; Rehabilitation
ISSN
ISI:000311656000023
Keywords :
Autism, Transforming growth factor-beta 1, IL-23, IL-17
Abstract:
It has been recently shown that dysregulation of transforming growth factor-beta 1 (TGF-beta 1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-beta 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-beta 1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6-12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-beta 1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-beta 1 with IL-17 in children with ASD. There was a negative correlation between TGF-beta 1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. (C) 2012 Elsevier Ltd. All rights reserved.
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