Abstract: Introduction: Partial pulpotomy is a vital treatement of carious and traumatic pulp exposure. Cell based therapy for Partially pulpotomised teeth can be considered as a promising approach for dentin-pulp complex regeneration Aim of the work: The aim of this study is to evaluate the healing capacity of autologous bone marrow derived stem cells on Partially pulpotomised teeth in dog model. Materials and methods: Twelve pathogen free male dogs 1year of age were selected and devided to two groups (group 1,2), 6 dogs for each group. A total of 192 posterior mandibuler and maxillary teeth were involvedin the study (16 teeth\dog). Partial pulpotomies were performed. The coronal pulp cavity wre filled with calcium silicate based capping material (biodentin) in group 1 while group 2 coronal pulp were filled with 1x105 cell\ml BMSCs then cavities were filled with resin modified glass ionomer restorative material. From each group 48 teeth from 3 dogs were evaluated histologically after 1 week and the remaining 48 teeth were evaluated histologically after 9 weeks. Results: Group 1 after 1 week show normal organization of pulp tissue with moderate inflamatory cell infiltrate and tssue necrosis without dentine bridge formation or pulp regeneration. In group 2 after 1 week show normal organization of pulp tissue with mild inflamatory cell infiltrate without tissue necrosis with initial dentine bridge formation or pulp regeneration. Group 1 after 9 week show normal organization of pulp tissue with minimal inflamatory cell infiltrate and tssue necrosis with a completely formed osteodentin bridge having tunnel deffect. In group 2 after 9 week show normal organization of pulp tissue without inflamatory cell infiltrate without tssue necrosis with completely formed dentine bridge formation and pulp regeneration. Conclusion: BMSCs have significant therapeutic potential because they inhance the healing capacity of partially pulpotomised dog's teeth.