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The Association of Serum Estradiol Level with the Susceptibility and Clinicopathological Features of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Nearmeen Mohammed Rashad Ahmmad
Staff Zu Site
Abstract In Staff Site
Journal:
Med. J. Cairo Univ Med. J. Cairo Univ
Volume:
Keywords :
, Association , Serum Estradiol Level with , Susceptibility
Abstract:
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The most common underlying causes of Hepatocellular car-cinoma (HCC) are chronic liver diseases and cirrhosis. Aim of Study: Our study aimed to investigate the serum estradiol levels in patients with nonalcoholics steatohepatitis (NASH) related HCC and to explore their correlations with clinicopathological features of HCC. Patients and Methods: A Controlled Cross-Sectional Study included 200 patients with NAFLD (181 patients with NAFLD and 23 patients with NAFLD related HCC) and 50 controls. Serum estradiol was measured by enzyme-linked immuno-sorbent assay (ELISA). Results: The serum level of estradiol was significantly lowered in patients with NAFLD (32.24±7.3pg/ml) compared to controls (42.9±3.9pg/ml). Moreover, our findings revealed lower concentrations of serum estradiol in the HCC group (28.6±5.3pg/ml) compared to the NAFLD group (33.45 ±4.3pg/ml, p<0.00 1). We found significant negative correla-tions between serum estradiol levels and clinicopathological features of HCC (portal vein thrombosis, lymph node metas-tasis, number of tumor lesions, advanced clinical stage, tumor size, tumor site, distant metastasis) in patients with NAFLD complicated with HCC. linear regression test and we observed that serum triglycerides and a-fetoprotein were significantly associated with serum estradiol among the HCC group. Conclusion: Serum estradiol level was significantly low-ered in the HCC subgroup compared to the NAFLD group and negatively correlated with clinicopathological features of HCC. Serum estradiol can be used as a promising predictor of HCC in female patients with NAFLD.
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Department Related Publications
Ahmed Adel Hassan Muhamad, "دراسة سريرية مرضية لالتهاب الكبد الهلالى المتكاثر عند الاطفال", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "ثبات وظائف الكلى المزروعة فى المستقبلون للكلى ويعالجون بعقار السانداميسون متابعة طويلة المدى", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "دراسة الاجسام المضادة لمضادات الكارديولابيبين ومتلازمة الكارديولابيبين فى مرضى الروماتويد المفصلى", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "الاجسام المضادة السامة للخلايا الليمفاوية للزوج فى حالات ارتفاع ضغط الدم المصاحب للحمل", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "تأثير من انظمة التثبيط المناعى على انتاج مادة عوامل النمو المحولtof-B1 فى متلقى زرع الكلى", لايوجد, 1900
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