Working women are exposed to many stressors especially in the medical field which affect their well being and marital satisfaction. Individual perception of high Work Life Balance (WLB) and sense of well being has become vital for any organization in order to ensure enhanced performance efficiency. Aim of work: To assess the effect of quality of working life on psychological wellbeing and marital satisfaction among married resident females and to assess the effect of psychological wellbeing on marital satisfaction. Materials and methods: A cross- sectional study was conducted on 100 married resident females in different clinical departments at Zagazig University hospitals. Standardized scales were used to gather information including the Quality of Work Life (QOWL) scale, Ryff ̛s Psychological Well-Being (PWB) scale and Enrich Marital Satisfaction (EMS) scale along with semi-structured questionnaire for sociodemographic data. Results: This study showed that the majority of our sample (70.0%) had low QOWL, 86.0% with low psychological well being and 75.0% with poor marital satisfaction and there were statistical significant direct correlation between QOWL and psychological wellbeing & marital satisfaction; also between psychological well being and marital satisfaction. Conclusion and recommendations: the results of this study attract the attention to the high work-stress situation among medical staff and the reciprocal effects of job satisfaction, psychological well being and marital satisfaction. These results should be considered by health policy decision makers when providing facilities such as educational programs for empowering couples, encourage periodic medical and health assessments of medical staff, and providing psychological and family consulting services at the workplace.