This study was conducted to evaluate safety and efficacy of dual trigger of oocyte maturation in comparison with conventional agents for high responders. 122 women distributed into two groups (61 women in both two group) to compare number of oocytes retrieved and OHHS risk in dual trigger group in comparison with HCG trigger group. Women in the study group were significantly younger (p≤0.003), no significant differences in BMI (p≥0.6), etiology or duration of infertility (p≥0.2), basic sex hormone levels (LH: p≥0.1, FSH: p≥0.1, E2: p≥ 0.4). no significant difference were recorded regarding the number of follicles measuring ≥10 mm in diameter. On the other hand, high quality embryos (p≤0.004) and number usable embryos (p≤0.001) and number of transferred embryo (˂0.001) were significantly higher in dual trigger group. Our results suggested that administration of dual trigger consisting of GnRH-a and low dose HCG is probably safe and effective method of triggering final oocyte maturation in cases of high responders in comparison with conventional triggering with standard dose HCG