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Prognostic Value of Percentage of Positive to Total Excised Axillary Lymph Nodes in Egypt with Triple Negative Breast Cancer: Multiple-Centers Experience
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Alaa Abdelhamied Bahgat Fayed
Staff Zu Site
Abstract In Staff Site
Journal:
international journal of life sciences international journal of life sciences
Volume:
Keywords :
Prognostic Value , Percentage , Positive , Total Excised
Abstract:
Background: The total number of axillary lymph nodes [LNs] is the most important prognostic factor in breast cancer. Over long times, different studies indicated that the lymph node ratio [LNR] might predict outcome better than the number of positive LNs. The aim of this retrospective study was to evaluate prognostic value of the lymph node ratio [LNR] in triple negative breast cancer [TNBC]. Materials and Methods: sixty patients with triple negative breast cancer [TNBC] at Zagazig University Hospitals and Fakous Cancer Center were included. We analyzed the impact lymph node ratio [LNR] on the disease free survival [DFS] and overall survival [OS] [calculated by Kaplan–Meier method]. Results: our results showed that the optimal cut off value of LNR value was 0.65, and the optimal cut off value of PLN. The Kaplan–Meier survival analysis showed the higher value of Mean disease free survival among all patients was 33.21 months and 3 year DFS was 50.6%. Disease free survival was significantly longer in those with LNR ≤ 0.65 than those with LNR > 0.65 [Mean: 33.34 months versus 27.46 months; 3year DFS 56.4% versus 36.9% respectively]. Mean overall survival among all patients was 36.90 months and 3 year OS was 50.4%. Overall survival was significantly longer in those with LNR ≤ 0.65 than those with LNR > 0.65 [Mean: 39.40 months versus 29.63 months; 3 year OS 73.8% versus 23.3% respectively]. Conclusion: These results suggest that TNBC patients with lower value of LNR good prognosis than with high LNR patients. The LNR is an independent prognostic factor, thus, LNR may be added to the current staging system.
Author Related Publications
Alaa Abdelhamied Bahgat Fayed, "COMPARISON OF HIGH-DOSE-RATE AND LOW-DOSE-RATE BRACHYTHERAPY IN THE TREATMENT OF ENDOMETRIAL CARCINOMA", Elsevier, 2007
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Alaa Abdelhamied Bahgat Fayed, "Percutaneous local injection of combined ethanol and mitoxantron versus radiofrequency ablation in treatment of Hepatocellular Carcinoma.", marsland press, 2015
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Alaa Abdelhamied Bahgat Fayed, "Evaluation of Different Radiotherapy Schedules In Brain Metastases", marsland press, 2013
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Alaa Abdelhamied Bahgat Fayed, "Addition of Daily Synchronous 3-Dimensional Conformal Boost to Gross Tumor Volume in Concurrent Chemoradiation plus Adjuvant Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma", marsland press, 2015
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Alaa Abdelhamied Bahgat Fayed, "Correlations between P53 mutations and response to Paclitaxel/Cisplatin Chemotherapy in Patients with Advanced Epithelial Ovarian Cancer", marsland press, 2015
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Department Related Publications
Rehab Hemida Elsayed Muhammad, "Snail-1, ALDH1, and claudin-1 tissue protein expression in patients with colorectal cancer: clinicopathological and prognostic implications تعبير بروتين الأنسجــة SNAIL-1و ALDH1 و claudin-1 في مرضى سرطان القولون والمستقيم: الآثار الإكلينيكية والتنبؤية", Egyptian Journal of Pathology, 2019
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Rehab Hemida Elsayed Muhammad, "Pelvic Lymphadenectomy, and Pelvic and Para-Aortic Lymphadenectomy Versus No Lymphadenectomy for Endometrial Cancer إستئصال العقد اللمفية في الحوض ، وإستئصال العقد اللمفية في الحوض والشريان الأورطي إستئصال العقد اللمفية مقابل عدم إستئصال العقد اللمفية لسرطان الرحم", JOURNAL OF GYNECOLOGIC SURGERY, 2019
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Rehab Hemida Elsayed Muhammad, "Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study الدلالات التنبؤية لتعبير NEDD-9 و FOXL-1 في سرطان المـعـدة من النوع المعوي: دراسة كيميائية مناعية", Journal of Gastrointestinal Cancer, 2020
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Rehab Hemida Elsayed Muhammad, "The value of fertility-sparing surgery for young females with epithelial ovarian cancer: a comparative study قيمة جراحة الحفاظ على الخصوبة للشابات المصابات بسرطان المبيض: دراسة مقارنة", CURR GYNECOL ONCOL, 2021
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Rehab Hemida Elsayed Muhammad, "prOgnOstic and clinicOpathOlOgicalimplicatiOns Of expressiOn Of Beclin-1 and hypOxia-induciBlefactOr 1α in serOus Ovarian carcinOma: an immunOhistOchemical study. الآثار الإنـذارية والإكلينيكية للتعبير عن بروتين بيكلين-1 والعامل المحرض بنقص الأكسجة ألفا 1 في سرطان المبيض الاستسقائي: دراسة كيميائية مناعية", Polish Journal of Pathology, 2021
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