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Radical Conformal Radiotherapy versus Two-Dimensional Radiotherapy in Oligometastatic Breast Cancer Patients: Response, Toxicity, and Survival
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Amira Elwan Mohamed Ahmad
Staff Zu Site
Abstract In Staff Site
Journal:
Zagazig university medical journal Zagazig university medical journal
Volume:
Keywords :
Radical Conformal Radiotherapy versus Two-Dimensional Radiotherapy
Abstract:
Background:oligometastatic breast cancer patients achieved better progression-free survival without significant toxicity, so this urge patients subgroups identification who might gain more benefit from aggressive local therapy. In comparison to antro posterior, post anterior, and direct post anterior techniques, 3-dimensional conformal irradiation delivered for treatment of lumbar vertebrae metastasis was much better in the decrease of bowel and spinal cord exposure. Aim of the work: to evaluate clinical outcome gains achieved by 3D radiotherapy versus 2D radiotherapy in certain breast cancer patients with bony oligo metastasis with expected favorable survival.Methods: Ina retrospective cohort, 60 patients were enrolled in 2D versus 3D arm. Treatment and survival outcomes were observed. Results: 3D radiotherapy offer a significantly better pain response, local control, and lower toxicity than patients were received treatment delivery by 2D radiotherapy with p-value = 0.004,0.002 and 0.004 respectively, patients were delivered 2D radiotherapy had shown a progressive disease than those treated by 3D radiotherapy of statistical significance p-value = 0.01. The 3D arm was better than the 2D arm in the term of better significant PFS and nonsignificant OS, p-value = 0.04, 0.14 respectively. Conclusion:3D conformal radiotherapy is of great value in the improvement of local control, pain response, progression-free survival, and overall survival with a tolerable toxicity profile in breast cancer patients diagnosed with bony oligo metastasis.
Author Related Publications
Amira Elwan Mohamed Ahmad, "Outcome of radiotherapy using prone versus supine treatment position in breast cancer patients with conservative surgery", Cancer biology, 2016
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Amira Elwan Mohamed Ahmad, "Prognostic Value of Aquaporin-3, Vimentin and E-cadherin Expressions in Invasive Breast Carcinoma: An Immunohistochemical Study", Middle East Journal of Cancer, 2020
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Amira Elwan Mohamed Ahmad, "Clinicopathological and Prognostic Value of Immunohistochemical Expression of CD44 (Stem Cell Marker) and Ki67 in Serous Ovarian Cancer", clinical and diagnostic research, 2019
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Amira Elwan Mohamed Ahmad, "Clinicopathological Features and Treatment Challenges in Triple Negative Breast Cancer Patients: A Retrospective Cohort Study", Turkish Journal of Pathology, 2021
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Amira Elwan Mohamed Ahmad, "Prognostic significance of peroxisome proliferator-activated receptor-gamma (PPAR-γ) and Cyclin D1 in bladder urothelial carcinoma", Zagazig University medical jou, 2020
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Department Related Publications
Rehab Hemida Elsayed Muhammad, "Snail-1, ALDH1, and claudin-1 tissue protein expression in patients with colorectal cancer: clinicopathological and prognostic implications تعبير بروتين الأنسجــة SNAIL-1و ALDH1 و claudin-1 في مرضى سرطان القولون والمستقيم: الآثار الإكلينيكية والتنبؤية", Egyptian Journal of Pathology, 2019
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Rehab Hemida Elsayed Muhammad, "Pelvic Lymphadenectomy, and Pelvic and Para-Aortic Lymphadenectomy Versus No Lymphadenectomy for Endometrial Cancer إستئصال العقد اللمفية في الحوض ، وإستئصال العقد اللمفية في الحوض والشريان الأورطي إستئصال العقد اللمفية مقابل عدم إستئصال العقد اللمفية لسرطان الرحم", JOURNAL OF GYNECOLOGIC SURGERY, 2019
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Rehab Hemida Elsayed Muhammad, "Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study الدلالات التنبؤية لتعبير NEDD-9 و FOXL-1 في سرطان المـعـدة من النوع المعوي: دراسة كيميائية مناعية", Journal of Gastrointestinal Cancer, 2020
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Rehab Hemida Elsayed Muhammad, "The value of fertility-sparing surgery for young females with epithelial ovarian cancer: a comparative study قيمة جراحة الحفاظ على الخصوبة للشابات المصابات بسرطان المبيض: دراسة مقارنة", CURR GYNECOL ONCOL, 2021
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Rehab Hemida Elsayed Muhammad, "prOgnOstic and clinicOpathOlOgicalimplicatiOns Of expressiOn Of Beclin-1 and hypOxia-induciBlefactOr 1α in serOus Ovarian carcinOma: an immunOhistOchemical study. الآثار الإنـذارية والإكلينيكية للتعبير عن بروتين بيكلين-1 والعامل المحرض بنقص الأكسجة ألفا 1 في سرطان المبيض الاستسقائي: دراسة كيميائية مناعية", Polish Journal of Pathology, 2021
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