Background: stimulation of the PPAR-γ axis was efficient in inhibiting the propagation of human bladder cancer cells through various pathways, in part joining to Cyclin D1, so this study aimed to evaluate the role of PPAR-γ and Cyclin D1 expressions in both non-invasive and invasive muscle urothelial carcinoma patients. Methods: This study was carried out using 80 paraffin-embedded specimens of urothelial carcinoma of them non-muscle invasive carcinoma (N=44) and invasive muscle carcinoma (N=36). Non-invasive carcinoma shown (65.9%) with low grade and (34.1%) with high grade while invasive carcinoma showed (33.3%) with low grade and (66.7%). According to staging, non-invasive reported (75%) Ta, (25%) T1 while invasive carcinoma reported (61.1%) T2, (27.8%) T3, (11.1%) T4.Immunohistochemical staining was achieved to study the association between PPAR-γ and Cyclin D1 expressions with the clinicopathological parameters and its prognostic outcomes. Results: positive expression of PPAR-γ and Cyclin D1 were significantly related to the higher tumor grade, further lymph node metastasis, and progressive tumor stage. Both positive PPAR-γ and Cyclin D1 expression were significantly connected with overall survival and disease-free survival . A significant positive association between PPAR-γ and Cyclin D1 expressions were found (p<0.001). Conclusion: the expressions of PPAR-γ and Cyclin D1 are related to the progression of bladder urothelial carcinoma, as well as advanced-stage and presence of lymph node metastasis. Evaluation of PPAR-γ and Cyclin D1 expression could help is assessment of infiltrative detection ability of urothelial carcinoma and benefitted as prognostic factors for patients with bladder tumor.