ABSTRACT Background: Different therapeutic options can be used for post-acne scarring. Scar subcision alone or in combination with other treatments have been used by many dermatologists to treat postacne scarring. Objectives: We thought to study and compare the efficacy and safety of scar subcision combined with platelet gel injection versus scar subcision combined with PRP injection for atrophic postacne scarring. Patients and methods: Scar subcision was done 1st on both sides of the face. Plasma gel injection was done on the right side and PRP injection was done on the left side. The sessions were done monthly for 4months followed by a 6-month follow-up period. Evaluation of the results and any complications were recorded. Results: There was a significant improvement (p¼.035) of the scars on the subcision-gel-side at one month following the 1st treatment session. However, along with the following sessions, there were no significant differences between both sides. Finally, at the follow-up visit after 6months following the end of the treatment course there was a significant difference between the two sides of the face in favor of the subcision-gel-side. Conclusions: Subcision combined with autologous plasma gel injection is a successful technique for atrophic post-acne scars. Abbreviations: PRP: Platelet rich plasma; IRB: Institutional Review Board; GAIS: global esthetic improvement scale