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Expression of Stem Cell Marker OCT4 and Epidermal Growth Factor Receptor Predict 3 Recurrence in Transitional Cell Carcinoma of Bladder in Egyptian Patients
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Mona Mostafa Ahmed Muhamd
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Clinical and Diagnostic Research Journal of Clinical and Diagnostic Research
Volume:
Keywords :
Expression , Stem Cell Marker OCT4 , Epidermal
Abstract:
Introduction: In the past, the prognosis of bladder cancer was dependent on the presence of muscle invasion. Recently High-Grade T1 (HGT1) Transitional Cell Carcinoma (TCC), found to be associated with similar behaviour and prognosis even following Bacillus Calmette Guerin (BCG) therapy. Recognition of new markers that may help in selection of high-risk cases that need aggressive treatment even in the early stage to avoid unwanted toxicity of chemotherapy has to be high priority. Aim: To evaluate the prognostic value of Octamer-Binding Transcription Factor 4 (OCT4) and Epidermal Growth Factor Receptor (EGFR) immunohistochemical expression in urothelial carcinoma of the bladder and their effect as well as the vascular invasion on the recurrence of these tumours. Materials and Methods: Prospective cohort study conducted in Zagazig University hospital from January 2010 till December 2013. Immunohistochemical staining of OCT4, EGFR and Cd34 for 68 cases of bladder cancer samples was done. The correlation between the expressions of each marker and clinic-pathologic parameters was then analysed. R esults: OCT4 was detected in 53 patients (77.9%) of total cases. EGFR showed high expression in 25 of cases. 18 and 25 cases revealed low and no EGFR expression, respectively. There was a significant association between intensity of OCT4 expression and tumour grade (p<0.001), muscle invasion (p<0.001), vascular invasion (p=0.004) and stage (p=0.001). Significant association was established between EGFR expression and tumour size, grade, lamina propria, muscle and vascular invasion and stage (p 0.005, <0.001, 0.001, <0.001, respectively). Significant association observed between OCT4, EGFR expression and vascular invasion and recurrence (p=0.026, 0.001 and 0.002 respectively). C onclusion: Using selective inhibitors for EGFR and OCT4 especially that approved for EGFR in treating selected cases of urothelial carcinoma of bladder could suppress tumour growth. These markers in addition to presence of vascular invasion have to be used in screening of high risk noninvasive group that benefits from target therapy.
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Mona Mostafa Ahmed Muhamd, "Expression of immunomodulator programmed death ligand 1 and fork head box protein 3 in squamous cell carcinoma of cervix", Egyptian Journal of Pathology, 2018
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Mona Mostafa Ahmed Muhamd, "INFLUENCE OF SELENIUM ON MONO SODIUM GLUTAMATE AS FOOD ADDITIVE INDUCED HEPATOTOXICITY AND TESTICULAR TOXICITY IN ADULT ALBINO RATS", ypt J. Forensic Sci. Appli. Toxicol, 2018
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Mona Mostafa Ahmed Muhamd, "ENHANCER OF ZESTE HOMOLOG 2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IMMUNOHISTOCHEMICAL EXPRESSION ARE ASSOCIATED WITH ADVERSE CLINICAL OUTCOME IN NON-METASTATIC CLEAR CELL RENAL CELL CARCINOMA.", Int. J. Adv. Res, 2017
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Mona Mostafa Ahmed Muhamd, "Expression of enhancer of zeste homolog 2 and cytokeratin 5/6 in triple negative versus non-triple negative breast cancer: An immunohistochemical study.", International Journal of Advanced Research, 2016
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Mona Mostafa Ahmed Muhamd, "Diagnostic Utility of Immunohistochemical Expressions of IMP3 Versus DOG1 and p63 in Salivary Gland Tumors", Turkish Journal of Pathology, 2020
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