Syzygium aromaticum (Clove) and Nigella sativa (N. sativa), are two valuable herbs known well for their medicinal effects and nutritional value. During this study, both herbs expressed high antioxidant effects with advantage for Syzygium aromaticum (Clove) over Nigella sativa (N. sativa). Methanol extract of Syzygium aromaticum (Clove) and Nigella sativa (N. sativa) expressed strong antimicrobial effect comparing to Chloroform extract. Syzygium aromaticum (Clove) contained high amounts of total flavonoids, total phenol, totalamino acid and carbohydrates contents than Nigella sativa (N. sativa). Gas Chromatography for methanol extract of both herbs also performed. Analyses of macro and micro elements showed that both herbs contain high amounts of elements. The present work walk in the same way that consider Syzygium aromaticum (Clove) and Nigella sativa (N. sativa), are two of the most important medicinal and nutritional herbs being used all over the world for almost on daily basis.