Pomegranate fruits have been commonly used in herbal remedies by local healers in many countries. In this work, total phenolic, flavonoid and anthocyanin contents of different parts of pomegranate fruit (peel, flesh, seeds, and whole fruit) were evaluated using two different solvents (methanol and ethyl acetate). The highest total phenolic and flavonoid contents were detected in peel methanol extract (103.2 mg/g dw and 132.4 mg/g dw) respectively. Also, the highest anthocyanin content was detected in peel extract (3.86 mg/g fw). HPLC coupled with diode-array detection was used to investigate the major phenolic compounds in peel methanolic extract. Among the phenolic compounds, chlorogenic acid, rutin and coumaric acid are present predominantly in the peel extract. Furthermore, the peel methanol extract exhibited the highest antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) and the ferric reducing antioxidant power (FRAP) assays. The high antioxidant activities of peel extract may be attributed to its high contents of total phenolic and total flavonoid. The results clearly indicate that pomegranate peel extract appeared to havemore potential effects as a health supplement rich in natural antioxidants than other parts.