The aim was to evaluate the performance, economics of production and physiological status of native Baladi and crossbred (50% Brown Swiss:50% native Baladi) calves under hot summer climate in Egypt (twenty-eight growing calves; 14 calve from each genetic type). The crossbred calves showed a significantly higher daily feed intake and body gain (p = 0.015 and 0.001 respectively), as well as a better feed conversion ratio (p = 0.019) compared with native Baladi calves. Although no significant differences were reported In the variable and total costs, the crossbred calves showed significantly greater total returns, net profit and Profit/Cost ratio when compared with native calves (p = 0.014, 0.001 and 0.022, respectively). The native Baladi calves had significantly higher serum glucose level compared with crossbred calves (p = 0.031). However, the crossbred calves showed a significantly higher serum Triiodothyronine (T3) level when compared with native calves (p = 0.016). Under a hot summer climate, no significant variations were reported in the rectal temperature, respiration rate, and daily water intake, as well as in the serum cortisol (p = 0.114) and thyroxin (p = 0.197) levels between native and crossbred calves. In conclusion, the crossbred calves exhibit a better growth performance, economic efficiency and stable physiological responses compared with the native calves under hot environment in the summer season.