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Generic daclatasvir plus sofosbuvir, with or without ribavirin, in treatment of chronic hepatitis C: real-world results from 18 378 patients in Egypt.
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
421-431
Authors:
Munkez Mutee Yusuf Muhamed
Staff Zu Site
Abstract In Staff Site
Journal:
Alimentary Pharmacology & Therapeutics John Wiley & Sons Ltd
Volume:
3
Keywords :
Generic daclatasvir plus sofosbuvir, with , without
Abstract:
Background: Treatment of chronic hepatitis C using combination of sofosbuvir (SOF) and daclatasvir (DCV) was used in several clinical trials and multicentre studies, which were somewhat limited to genotypes 1-3. The national program in Egypt is using SOF-DCV combination for large scale treatment. Aim: To assess the efficacy and safety of combined SOF-DCV in treating patients with HCV-G4 in a real-world setting. Methods: Data and outcome of chronic HCV patients who were treated for 12 weeks with generic medications: DCV 60 mg plus SOF 400 mg ribavirin (RBV) within the national hepatitis C treatment program in Egypt are presented. Treatment- na€ıve patients without cirrhosis were treated without RBV, and those who had cirrhosis or were treatment-experienced (interferon experienced or SOF experienced) received RBV. Efficacy and safety were assessed, and baseline factors associated with sustained virological response at post-treatment week 12 (SVR12) were explored. Results: During the first 2 months of the programme, 18 378 patients with HCVG4 started treatment with SOF-DCV with or without RBV. Overall, 95.1% achieved SVR12 (95.4% among patients treated without RBV and 94.7% for patients treated with RBV, P = .32). Treatment was prematurely discontinued in only 1.5% of patients. The most common events leading to discontinuation were patient withdrawal (n = 76) and pregnancy (n = 5). Five deaths occurred within this group. Conclusions: Real-world experience of generic SOF-DCV in patients with chronic HCV-G4 proved to be safe and associated with a high SVR12 rate, in patients with different stages of fibrosis.
Author Related Publications
Munkez Mutee Yusuf Muhamed, "دراسة التغيرات فى حركية المرى لدى مرضى التهاب المفاص الرثياخى", لايوجد, 1900
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Munkez Mutee Yusuf Muhamed, "دراسة شكل طفيل بلاستوسيتس هومينيس ودورة الاكلينكى كسبب للاسهال عند المرضى المصابين بخلل فى الجهاز المناعى", لايوجد, 1900
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Munkez Mutee Yusuf Muhamed, "القيمة التنبؤية لبعض الفحوصات الاكلينكية والمعملية عند مرض الذبحة الصدرية غير المستقرة ودورها فى تقييم المرضى حسب درجات الخطورة", لايوجد, 1900
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