Effect of Obesity on Neoadjuvant Systemic Therapy Outcomes in Patients with Early Breast Cancer: A Retrospective Institutional Study

Faculty	Medicine	Year:	2020
Type of Publication:	ZU Hosted	Pages:
Authors:
Journal:	Asian Pacific Journal of Cancer Prevention ASIAN PACIFIC ORGANIZATION CANCER PREVENTION	Volume:

Keywords :	Effect , Obesity , Neoadjuvant Systemic Therapy Outcomes
Abstract:	-Obesity and overweight are usually considered as poor prognostic factors in early breast cancer. Body mass index (BMI) is a significant predictive factor for lower pathologic complete response (pCR) rates after neo-adjuvant systemic therapy (NST). The relationship between obesity and breast cancer prognosis varies according to patient and tumor characteristics such as menopausal status and tumor subtype, respectively. -In the present study, 58.3% of patients that failed to achieve pCR had BMI above the normal level; they moreover had higher relapse rates and lower survival compared with normal BMI patients. This finding needs to be verified through further prospective studies to determine if BMI is a risk factor for breast cancer.

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