Effect of Obesity on Neoadjuvant Systemic Therapy Outcomes in Patients with Early Breast Cancer: A Retrospective Institutional Study

Faculty Medicine Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Asian Pacific Journal of Cancer Prevention ASIAN PACIFIC ORGANIZATION CANCER PREVENTION Volume:
Keywords : Effect , Obesity , Neoadjuvant Systemic Therapy Outcomes    
Abstract:
-Obesity and overweight are usually considered as poor prognostic factors in early breast cancer. Body mass index (BMI) is a significant predictive factor for lower pathologic complete response (pCR) rates after neo-adjuvant systemic therapy (NST). The relationship between obesity and breast cancer prognosis varies according to patient and tumor characteristics such as menopausal status and tumor subtype, respectively. -In the present study, 58.3% of patients that failed to achieve pCR had BMI above the normal level; they moreover had higher relapse rates and lower survival compared with normal BMI patients. This finding needs to be verified through further prospective studies to determine if BMI is a risk factor for breast cancer.
    
     
 
       

Author Related Publications

    Department Related Publications

    • Heba Fekry Abdel Majid Taha, "Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions", springer, 2018 More
    • Tarek Ali Mohamed Elgohary, "Study of Minimal Residual Disease in Adults with B-Lineage Acute Lymphoblastic Leukemia by Flowcytometry. دراسة الحد الأدنى للمرض المتبقي عند البالغين الذين يعانون من سرطان الدم اللمفاوي الحاد - بي بواسطة جهاز التدفق الخلوي", Journal of Cancer Therapy, 2017, 8, 386-398, 2017 More
    • Amarallah Abdelmoneim Mohamed Sayed, "Impact of vitamin D serum levels on clinicopathological features and outcome in advanced pancreatic carcinoma", Sciendo, 2019 More
    • Shereen Mostafa Saleh Elshorbagy, "The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study", THIEME, 2022 More
    • Shereen Mostafa Saleh Elshorbagy, "Abbreviated Concurrent Chemo-Radiotherapy in NodeNegative Muscle-Invasive Bladder Cancer", SECI Oncology Journal, 2021 More
    Tweet