This study aims to discuss the evolution of the global and domestic consumption and production of nitrogenous fertilizer, and to determine the most important factors affecting the use of nitrogenous fertilizer in the Egyptian agriculture. To achieve these objectives, the study depended on secondary data for the period 2000-2016. The statistical method includes the step-wise multiple regression analysis, and the linear functions. The main results of the study were: these is statistical significance increase in the global production of the nitrogenous fertilizers by 2 million ton annually, these is statistical significance decrease in the domestic production by 0.29 million ton. The total quantities available for global consumption increased by 2 million ton. The quantities available for domestic consumption decreased by 0.19 million ton, because of the decrease in the imports and the increase in the exports. This result is considered as an indicator of rationing the use of nitrogenous fertilizers. The results indicated also that the most important factors affecting the use of nitrogenous fertilizers were the price of nitrogenous fertilizer 15.5%, the price of organic manure fertilizer and total cropping area.