This study investigates the performance of Hot Mix Asphalt concrete mixtures modified using different types of traditional and Nano additives. The traditional modifiers include rubber, polyethylene and lime while the Nano modifiers include Nano Silica (NS) and Silica Fume (SF). The performance of the modified mixtures is comparatively evaluated in order to find the best modifier. The evaluation is done through conducting the comparison between results obtained on samples using Marshall, Indirect Tensile Strength, Direct Compression, and Wheel Tracking tests. The used samples are prepared and compacted at the optimum modifier percentage previously founded by other research studies. An economic study analysis for the direct cost of materials for production of 1 ton of the unmodified and modified mixtures is conducted. The results indicate that NS is considered the best modifier that achieved maximum stability, minimum flow, higher tensile strength; higher direct compression strength and lower rutting depth. On the second basis, SF is following NS in achieving relatively nearer results as NS whereas the other modifiers achieved lower mixture performance rates. The economic analysis indicates that the cost of producing 1 ton of mixture shall be very high cost and not capable to be applicable solution since it shall cost 27192 L.E using NS as a modifier of HMA. Excluding the NS from the economic analysis rating leads to bring the SF to be 14% increase in cost compared with the unmodified mixtures but with achieving most applicable improvement in mixture performance represented by mix stability, flow, direct compression resistance, indirect tensile strength and rutting resistance.