Clinical Outcomes of Upper Gastrointestinal Bleeding in Egyptian Patients with Decompensated Liver Cirrhosis, Does the Bleeding Source Matter?

Faculty Medicine Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Egyptian journal of hospital medicine Ain Shams University Volume:
Keywords : Clinical Outcomes , Upper Gastrointestinal Bleeding , Egyptian    
Abstract:
Background: Upper gastrointestinal bleeding (UGIB) is a prevalent emergency and mortality cause in cirrhotic patients. It prolongs the hospital length of stay (LOS) and increases hospital readmission. Objectives: We investigated the clinical outcomes of acute variceal bleeding (AVB) and non-variceal bleeding (NVB) in patients with decompensated cirrhosis and the possible risk factors for prolonged hospital LOS. Patients and Methods: All patients with decompensated liver cirrhosis and UGIB (AVB & NVB) hospitalized from August 2018 to March 2019 were enrolled in this study. We assessed mortality rate, the hospital LOS and hospital readmission rate along with the probable risk factors associated with prolonged hospital LOS. Results: Our study included 582 patients with decompensated liver cirrhosis, 367 patients had AVB and 215 patients had NVB. There was no significant difference in mortality rate between both groups (11.4% vs. 9.3%, P= 0.43). The hospital LOS in AVB patients was longer than that in NVB group (5.8 ± 2.2 vs. 4.3 ± 1.8, p=0.001). Rate of hospital re-admission within 30 days was significantly higher in the AVB group (27%) compared to NVB group (18%). Inhospital re-bleeding and the need for repeated endoscopy were also higher in AVB patients (20%) than in NVB patients (12%). Risk factors for prolonged hospital LOS were development of hepatic encephalopathy, spontaneous bacterial peritonitis (SBP), in-hospital re-bleeding, Child C score and higher Model for end-stage liver disease (MELD) score. Conclusion: Patients with decompensated cirrhosis and AVB have longer hospital LOS and re-hospitalization rate than those with NVB with no significant difference in mortality rate between both groups
   
     
 
       

Author Related Publications

  • Mohammed Ahmed Ali Bassiouni, "Sofosbuvir and daclatasvir plus ribavirin treatment improve liver function parameters and clinical outcomes in Egyptian chronic hepatitis C patients", Wolters Kluwer Health, Inc., 2017 More
  • Mohammed Ahmed Ali Bassiouni, "Lipocalin-2: A novel diagnostic marker for hepatocellular carcinoma", IOS press, 2020 More
  • Mohammed Ahmed Ali Bassiouni, "Management of HCV‑related decompensated cirrhosis with direct‑acting antiviral agents: who should be treated?", Springer, 2019 More
  • Mohammed Ahmed Ali Bassiouni, "Prevalence and Risk Factors of Minimal Hepatic Encephalopathy in Patients with Compensated Liver Cirrhosis", Ain Shams University, 2020 More
  • Mohammed Ahmed Ali Bassiouni, "The significance of bariatric surgery in Egyptian patients with metabolic syndrome: a multicenter study", Wolter Kluwer - MedKnow, 2020 More

Department Related Publications

  • Ahmed Adel Hassan Muhamad, "اكتشاف ظهور ال69 باستخدام جهاز تدفق الخلايا لا يعتبر دلالة على الاستجابة التكاثرية التى تحدثها خلايا المعطى لخلايا الملتقى ", لايوجد, 1900 More
  • Usama Mohamed Ahmed Hassanein, "الارتداد المصري بالمرئ المصحوب والغير مصحوب باعراض مرئية وعلاقتة بالاعراض الصدرية في مرض الربو الشعبي", لايوجد, 1900 More
  • Ehab Mohamed Ahmed Salm, "دراسة الخلل الوظيفى للجدار المبطن للاوعية الدموية في ابناء مرض السكري من النوع الثاني بطريقة غير تداخلية", لايوجد, 1900 More
  • Hamed Abdelaziz Deraz, "اكتشاف الاجسام المضادة للكابيلاريا هيا تيكا فى مرض الكبد فى محافظة الشرقية ", لايوجد, 1900 More
  • Helmy Mohamed Youssef Elgendy, "البلازما د- دايمر انتجين كمتبى لنزيف الجهاز الهضمى العلوى ونتائجة العكسية", لايوجد, 1900 More
Tweet