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Lipocalin-2: A novel diagnostic marker for hepatocellular carcinoma
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Mohammed Ahmed Ali Bassiouni
Staff Zu Site
Abstract In Staff Site
Journal:
Cancer biomarkers IOS press
Volume:
Keywords :
Lipocalin-2: , novel diagnostic marker for hepatocellular carcinoma
Abstract:
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Viral hepatitis, alcoholism and non-alcoholic steatohepatitis are the most common risk factors. Despite the advances in HCC screening and treatment options, HCC still has a high mortality rate and a high rate of recurrence after treatment. Lipocalin-2 (LCN-2) is a glycoprotein transporter that is highly expressed in HCC tissues. OBJECTIVE: To evaluate serum LCN-2 as a diagnostic marker for HCC. METHODS: The study was carried out in Zagazig university hospitals. It included 210 HCC patients (subdivided in three subgroups), 72 liver cirrhosis patients without HCC and 18 normal control persons (the total is 300 subjects). All the study subjects were evaluated by history taking, physical examination, routine laboratory investigations, alpha-fetoprotein (AFP) and LCN-2 in addition radiology. RESULTS: In comparison between HCC and control, there was a statistically significant difference in hemoglobin percent (HB%), platelet count, serum ALT, AST, ALP, bilirubin, albumin and creatinine. In comparison to AFP, LCN-2 > 225 ng/ml had a higher diagnostic performance in HCC patients and was more accurate in differentiation between cirrhosis and HCC patients. CONCLUSION: LCN-2 is a good candidate for HCC diagnosis and screening
Author Related Publications
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Mohammed Ahmed Ali Bassiouni, "Management of HCV‑related decompensated cirrhosis with direct‑acting antiviral agents: who should be treated?", Springer, 2019
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Mohammed Ahmed Ali Bassiouni, "The significance of bariatric surgery in Egyptian patients with metabolic syndrome: a multicenter study", Wolter Kluwer - MedKnow, 2020
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Department Related Publications
Ahmed Adel Hassan Muhamad, "التعدد الشكلى لجينات الصنف الثانى من مولدات المضادات المحمولة على كرات الدم البيضاء البشرية فى حالات اصابات الكلى المزروعة بارتجاع الالتهاب الكبدى الناتج عن الاجسام المضادة "أ"", لايوجد, 1900
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Usama Mohamed Ahmed Hassanein, "علاقة النحاس والسيريولوبلازمين بالمراحل المختلفة للاعتلال الكلوي السكري في مرض السكر من النوع الثاني", لايوجد, 1900
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Usama Mohamed Ahmed Hassanein, "دراسة الارتباط بين درجة احساس القرنية ودرجة تاثير الاعصاب الطرفية والشرايين في مرض السكر ", لايوجد, 1900
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Ehab Barsom Fahim Meawad, "البروتين المرتبط بالرتيينول فى البول كوسيلة لاكتشاف المبكر للاعتلال الكلوى السكرى ( تم اجراء الدراسة بمستشفيات جامعة الزقازيق)", لايوجد, 1900
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Ehab Barsom Fahim Meawad, "التشخيص المبكر للاستسقاء المقاوم للعلاج فى مرض التليف اكبدى باستخدام عقار الفيوريزيميد", لايوجد, 1900
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