For high plant growth and efficient production, manufacture of new ‎nanofertilizers is an important strategy to repair the nutrients shortage. ‎Copper ferrite nanoparticles (CuFe2O4 NPs) were manufactured via co-‎precipitation method with the aim to understand the role of different concentration of them (0.0, 0.04, 0.2, 1, and 5 ppm) on growth, chlorophyll content and ‎antioxidant enzymes activities of cucumber plants grown in hydroponic ‎system.‎‏ ‏The prepared sample was studied by various mechanisms such ‎as: X-ray diffraction (XRD), Infrared spectroscopy and vibrating sample magnetometer. XRD pattern implies the nanocrystalline nature of the ‎synthesized sample, where the crystallite size is 30.7 nm. Exposure to ‎CuFe2O4 NPs caused an increase in the fresh weight and protein content ‎of cucumber plants. Also, superoxide dismutase and peroxidase ‎activities of cucumber shoots and roots were significantly increased. The ‎uptake of Fe and Cu by cucumber tissues was significantly enhanced by ‎application of CuFe2O4 NPs ‎