Journal: |
Zagazig Journal of Pharmaceutical Sciences
Zagazig University
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Volume: |
30
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Abstract: |
[PDF] from ekb.eg
Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality
Authors
Asmaa M Abdelghafour, Nahla N Younis, Sally K Hammad, Hoda E Mohamed
Publication date
2021/6/1
Source
Zagazig Journal of Pharmaceutical Sciences
Volume
30
Issue
1
Pages
1-16
Publisher
Zagazig University; Faculty of Pharmacy
Description
Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved signaling which is not only important for regulation of embryogenesis and organ development, but also for injury repair, homeostasis and tissue remodeling. Dysregulation of this pathway either by upregulation or even downregulation is highly implicated in various diseases such as; liver diseases, kidney diseases, lung fibrosis, heart failure, vascular calcification, osteoporosis, cellular senescence, neurodegeneration, Alzheimer's disease and cancers. Thus, targeting Wnt/β-catenin signaling has attracted scientific research as a good strategy ameliorating several diseases. In this review we discussed Wnt/β-catenin components, the Wnt-on state and the Wnt-off state. Furthermore, we summarized the effects of Wnt/β-catenin signaling in several distinct organs including brain, bone, liver, heart, lung and kidney. We also discussed various molecules that act as modulators of Wnt/β-catenin signaling pathway via targeting its components (Wnt, Frizzled, LRP5/6, Porcupine, Disheveled, β-catenin destruction complex and β-catenin activity) aiming to show their possible therapeutic potential in several diseases.
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