Journal: |
Afro-Egypt J Infect Endemic Diseases
Afro-Egypt J Infect Endemic Diseases
|
Volume: |
|
Abstract: |
Background and study aim: Regarding
the increased number of chronic liver
diseases (CLD) patients suffering
from many manifestations e.g. diarrhea,
this withdrew our attention to try to find a
relation between CLD and parasitic
infections in those patients.
Patients and Methods: A case-control
study was performed on 190 participants
suffering from gastrointestinal complaints
especially diarrhea attending
Gastroenterology and Hepatology
Outpatient Clinics at Zagazig University
Hospital, divided into 2 groups GI: 95
CLD patients. GII: 95 non-CLD Control
group patients. Cases underwent clinical,
abdominal ultrasonographic, and
laboratory liver function assessments.
Also, collected patients’ stool samples
were microscopically examined using
iodine, Trichrome and Modified ZiehlNeelsen stains. To confirm accurate
diagnosis to parasitic infections causing
diarrhea, RIDA-ELISA
for Cryptosporidium spp. and Giardia
lamblia copro-antigens detections was
performed.
Results: Parasitic infections among both
studied groups were (47%), comprising
(58%) in CLD and (36%) in non-CLD as
follow: Cryptosporidium (28%, 14%),
Giardia (15%, 12%), mixed (5%, 3%),
E.histolytica spp. (5%, 4%), Blastocystis
hominis (3%, 1%) and H. nana (1%, 2%)
respectively. The sensitivity, specificity,
PPV, NPP and accuracy of ELISA
regarding Giardia and Cryptosporidium
infections were (100% and 89.6%, 97.5%
and 100%, 87.9% and 100%, 100% and
96.6%, 97.9% and 98.4%) respectively. In
GI, most giardial cases had normal ALT
and AST levels (74%, 63%), but elevated
in cryptosporidial infection (59%, 66%)
respectively, with statistically significant
difference.
Conclusion: Presence of intestinal
parasitic infections; mainly
Cryptosporidia and Giardia
protozoa among CLD patients was striking
when compared to diarrheic non-CLD
control group and this may be attributed to
impaired immune status.
|
|
|