Clinicopathological Features and Treatment Challenges in Triple Negative Breast Cancer Patients: A Retrospective Cohort Study

Faculty Medicine Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Turkish Journal of Pathology Federation of Turkish Pathology Societies Volume:
Keywords : Clinicopathological Features , Treatment Challenges , Triple Negative Breast    
Abstract:
Objective: As the genetic and molecular profiles of triple negative breast carcinoma (TNBC) are elucidated, multiple therapeutic targets have been produced. TNBC with less than 1% androgen receptor (AR) expression may respond to enzalutamide with greater response association in higher levels. A metronomic dose of capecitabine and docetaxel are effective developed drugs for angiogenic process inhibition. We aimed to demonstrate the treatment outcome of triple-negative breast cancer patients in correlation to their clinicopathological features. Materials and Methods: A retrospective cohort study of 80 TNBC patients was conducted. The patients underwent proper observation with the reporting of their treatment and follow-up data. Patients with a metastatic disease, neoadjuvant chemotherapy, follow-up drop or data shortage were excluded from the survival analysis. Results: The study results revealed a significant association between negative androgen expression and younger age ≤35 years, premenopausal status, higher grade, extracapsular extension, lymphovascular invasion, Ki 67, and CA15-3 (p=0.003, 0.02, <0.001, 0.001, 0.027, 0.005, 0.009 respectively). The three-year overall survival (OS) in patients who received bicalutamide was better than those patients who received capecitabine or docetaxel but of no significance (p=0.46). The three-year disease free survival (DFS) was significantly better in the bicalutamide arm versus the other two groups (p=0.012). Conclusions: We concluded that extended adjuvant antiandrogen such as bicalutamide and metronomic capecitabine are well tolerated with accepted compliance and affordability compared to docetaxel and are warranted for problem-solving and better DFS and OS in some TNBC patients.
   
     
 
       

Author Related Publications

  • Ahmed Abdelrehem Ahmed Abdulrihem, "The pattern of infection and antibiotics use in terminal cancer patients.", ELSEVIER, 2014 More
  • Ahmed Abdelrehem Ahmed Abdulrihem, "Significance of PAX (CDX2) gene expression in adult acute Myeloid leukemia", http://www.journalijar.com/, 2015 More
  • Ahmed Abdelrehem Ahmed Abdulrihem, "Emergency Department Visits at the End of Life of Patients With Terminal Cancer", sage journals, 2015 More
  • Ahmed Abdelrehem Ahmed Abdulrihem, "Clinico-Pathological Patterns and Survival Outcome of Colorectal Cancer in Young Patients: Western Saudi Arabia Experience", Volume 1, Issue 13, February, Pages 5239-5243, 2014, 2014 More
  • Ahmed Abdelrehem Ahmed Abdulrihem, "The Relation Between the Timing of Palliative Care and the Frequency and Timing of Do-Not-Resuscitate Orders Among Cancer Deaths in a Tertiary Care Hospital", American Journal of Hospice & Palliative Medicine, 2015 More

Department Related Publications

  • Heba Fekry Abdel Majid Taha, "Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions", springer, 2018 More
  • Tarek Ali Mohamed Elgohary, "Study of Minimal Residual Disease in Adults with B-Lineage Acute Lymphoblastic Leukemia by Flowcytometry. دراسة الحد الأدنى للمرض المتبقي عند البالغين الذين يعانون من سرطان الدم اللمفاوي الحاد - بي بواسطة جهاز التدفق الخلوي", Journal of Cancer Therapy, 2017, 8, 386-398, 2017 More
  • Ola Mohamed Ahmed Elfarargy, "Peripheral and Tissue Lymphocytes as Predictors of Pathological Response in Locally Advanced Rectal Cancer Post Neoadjuvant Chemoradiotherapy", scintific research publishing, 2017 More
  • Amarallah Abdelmoneim Mohamed Sayed, "Impact of vitamin D serum levels on clinicopathological features and outcome in advanced pancreatic carcinoma", Sciendo, 2019 More
  • Shereen Mostafa Saleh Elshorbagy, "The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study", THIEME, 2022 More
Tweet