Introduction :About 30 % of people are affected by allergic rhinitis (AR). Allergic rhinitis is an inflammatory condition defined by a disturbance of immunoregulation generating an amplified T helper "Th-2" response. An inflammatory mechanism mediated by HLA-G is thought to be involved through initiation of Th2 cytokine profile releasing "interleukin IL-3, IL-4, and IL-10". Objective:We evaluated levels of soluble HLA-G "sHLA-G" and studied its association with "allergen specific IgE" in AR patients. Patients and methods:Twenty-five AR patients and twenty healthy subjects were enrolled. sHLA-G levels (U/ml) were measured by an immunoenzymatic method, while specific IgE levels (IU/ml) of respiratory allergens were analyzed using immunoblotting assay. Results:AR group has significantly higher serum sHLA-G levels than normal subjects, P<0.001. There was a highly significant and positive correlation between sHLA-G levels and specific IgE levels of Alternaria alternate and Dermatophagoides pteronyssinus (P<0.01). Besides, there was a significant (P<0.05) positive correlation between sHLA-G levels and specific IgE levels of brich and mixed grasses. Conclusion: serum sHLA-G level is significantly increased in AR patients and that serum sHLA-G level could be a diagnostic biomarker in AR patients for clinical severity assessment.