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Mathematical modeling of female breast cancer in Japan
Faculty
Science
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Nagah Saeed Majid
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Biomathematics World Scientific Publishing Co. Pte Ltd
Volume:
Keywords :
Mathematical modeling , female breast cancer , Japan
Abstract:
Cancer incidence rates are significantly different all over the world. Breast cancer is affected by many factors, the most important being genetics and lifestyle. The aim of this paper is to study the mutation mechanisms of breast cancer for Japanese women by fitting the incidence data of three high-quality population areas in Japan from 1985 to 2010. To achieve this goal, we have set up multi-stage models within the mathematical model of Moolgavkar, Venzon, and Knudson. Such models take both mutation rates and clonal expansion rates as parameters in each compartment into consideration. Based on our simulation outcomes, two to twelve driver mutations are sufficient in the pathway to female breast cancer in Japan. On the other hand, a previous study demonstrated that breast cancer in American women requires two to fourteen gene mutations to get a cancerous cell. Moreover, the 3-stage mathematical model is the optimal model as it fits clinical data very nicely for all affected cases of females in Japan and the US. The genetic instability has a prominent effect on the tumorigenesis of Japanese females caused by the first four driver mutations. The calculated results for Japanese women are compared with previous works for American women.
Author Related Publications
Ahmed Nagah Saeed Majid, "Proton and antiproton impact excitation of H(2s) atom", Canadian Journal of Physics, 2015
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Ahmed Nagah Saeed Majid, "Optimal Control for Systems Described by Semi-linear Parabolic Equations", World Scientific and Engineering Academy and Society, 2018
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Ahmed Nagah Saeed Majid, "The effect of cigarette smoking on lung cancer evolution", Arizona State University, 2019
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Ahmed Nagah Saeed Majid, "Different Mechanisms of Cigarette Smoking‑Induced Lung Cancer", Springer Netherlands, 2020
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Ahmed Nagah Saeed Majid, "Mutation Mechanisms of Breast Cancer among the Female Population in China", Bentham Science Publishers B.V., 2020
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Rodyna Ahmed Mahmoud, "ON BCL-ALGEBRA", Council for Innovative Research, 2013
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Yasser AbdelAziz Amer Tolba, "The improved (G’/G) - expansion method for constructing exact traveling wave solutions for a nonlinear PDE of nanobiosciences", USA, 2013
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Alaa Hassan Attia Hassan, "A Unified Representation of Some Starlike and Convex Harmonic Functions with Negative Coefficients", AGH University of Science and Technology Press, Krakow 2013, Poland, 2013
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Alaa Hassan Attia Hassan, "Generalizations of Hadamard Procuct of Certain Meromorphic Multivalent Functions with Positive Coefficients", Istanbul Universitesi, Turkey, 2013
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