Intralesional immunotherapy by different antigens has shown promising efficacy andsafety in the treatment of warts. However, the use of these antigens for the treat-ment of plane warts has been investigated in two studies only. To evaluate the effi-cacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR), Candidaantigen, and purified protein derivative (PPD) in the treatment of multiple planewarts. The study included 120 patients who were randomly assigned to three groups,40 patients in each group. Each agent was injected intralesionally at a dose of 0.1 mLinto the largest wart at 2-week intervals until complete clearance or for a maximumof five sessions. Complete clearance of warts was observed in 55% of the PPD group,in 70% of the Candida antigen group, and in 62.5% of the MMR group. No statisti-cally significant difference in the therapeutic response was found between the threegroups. Intralesional antigen immunotherapy seems to be a promising well-toleratedand effective therapeutic option for the treatment of multiple plane warts, with rela-tively higher efficacy of Candida antigen