The use of trichloroacetic acid as a depigmenting therapy in universal vitiligo

Faculty Medicine Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Deutsche Dermatologische Gesellschaft Wiley Volume:
Keywords : , , , trichloroacetic acid , , depigmenting therapy , universal vitiligo    
Abstract:
Background and objectives: Several modalities have been used to clear residual facial pigmentation in patients with extensive vitiligo; however, the ideal depigmen-ting agent does not yet exist. The use of trichloroacetic acid (TCA) for depigmentation in universal vitiligo has been recently reported. We aim to evaluate the efficacy and safety of TCA 100 % as a depigmenting therapy for recalcitrant facial pigmentation in Egyptian patients with universal vitiligo.Patients and methods: The study included 50 patients with universal vitiligo who had residual spotted pigmentation on the face causing psychological distress. TCA was focally applied to cover the pigmented patches at 100 % concentration. The tre-atment was repeated every two weeks until complete depigmentation or for a maxi-mum of five treatment sessions.Results: Excellent response to TCA treatment (> 90 % depigmentation) was reported in 80 % of the studied cases, partial response (50–90 % depigmentation) in 12 % and poor response (< 50 % depigmentation) in 8 % of the cases. Minor adverse effects were reported e.g. burning sensation, erosions and local infection.Conclusions: TCA seems to be a cost-effective and well tolerated therapeutic option for the treatment of recalcitrant residual pigmentation in patients with extensive vitiligo. This modality is associated with reduced downtime and minimal adverse effects
   
     
 
       

Author Related Publications

  • Rania Abdulaziz Zaki Abedulaziz, "Lichen myxedematosus: toward established classification and diagnostic criteria: Response to the letter 'Lichen myxedematosus: suggestions on the newly proposed diagnostic criteria", Wiley, 2018 More
  • Rania Abdulaziz Zaki Abedulaziz, "Tender erythematous plaques over the neck of an infant.", ELSEVIER, 2017 More
  • Rania Abdulaziz Zaki Abedulaziz, "Lichen myxedematosus: diagnostic criteria, classification, and severity grading", Wiley, 2017 More
  • Rania Abdulaziz Zaki Abedulaziz, "A fatal case of febrile ulceronecrotic Mucha-Habermann disease in a child.", ELSEVIER, 2016 More
  • Rania Abdulaziz Zaki Abedulaziz, "An Egyptian boy with Haberland syndrome: Case report with observations on the histopathology.", ELSEVIER, 2015 More

Department Related Publications

  • Amany Abdelrahman Mohamed Abdulazyz, "The role of PCR in the diagnosis of dermatophytes in onychomycosis", med pub, 2019 More
  • Mohammed Mahmoud Abdel-Azim Nasr, "Serum prolactin level in chronic urticaria: Is bromocriptine inducing remission in chronic urticaria?", JOURNAL OF DERMATOLOGICAL TREATMENT, 2018 More
  • Fatheah Mohammed Ahmed Abdullah khattab, "Serum prolactin level in chronic urticaria: Is bromocriptine inducing remission in chronic urticaria?", JOURNAL OF DERMATOLOGICAL TREATMENT, 2018 More
  • Howeida Mohamed Ibrahim Hasn, "Serum prolactin level in chronic urticaria: Is bromocriptine inducing remission in chronic urticaria?", JOURNAL OF DERMATOLOGICAL TREATMENT, 2018 More
  • Fatheah Mohammed Ahmed Abdullah khattab, "Combined acitretin and Candida antigen versus either agent alone in the treatment of recalcitrant warts", Elsevier, 2018 More
Tweet