A 20 years old male student presented with fever (reaching 40 C), rigors, nausea, vomiting, abdominal pain and severe weakness for three weeks. He gave a history of staying in Sudan for 14 months from where he arrived to Egypt about three months before admission to Haematology Unit ,Internal Medicine and Tropical Medicine Departments ,Zagazig University Hospitals. He suffered from a similar attack about one year ago when he was in Sudan. The condition was diagnosed that time as malaria but the species was not defined. According to the patient, he was treated with lumifantrine artemether and improved. By examination of the patient, he looked very ill with severe pallor, and marked splenomegaly. His investigations showed Pancytopenia with (RBC 2.400,000/ul and hemoglobin 8.6 gm/dl), thrombocytopenia (platelets 100,000/ul) and leukopenia (3700/ul). ESR was high up to 110/ 1st hour and so CRP and LDH were also high. By ultrasound examination, the longitudinal diameter of his spleen was 18 cm. Multiple blood films were done and ring forms and gametocytes of Plasmodium falciparum were visualized. Diagnosis of Malaria infection was established and the species was defined as Plasmodium falciparum