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Activation of liver X receptors ameliorates alterations in testicular function in rats exposed to electromagnetic radiation
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Randah Salah Gomaa
Staff Zu Site
Abstract In Staff Site
Journal:
Alexandria Journal of Medicine Alexandria Journal of Medicine
Volume:
Keywords :
Activation , liver , receptors ameliorates alterations , testicular
Abstract:
Introduction: Cell phones are essential for modern life and their usage becomes prevalent. Worries have increased concerning the harmful effects of their radio-frequency electromagnetic radiation. Liver X receptors (LXRs) are ligand-dependent transcription factors that have important roles in lipid metabolism and inflammation, plus several recently emerging roles. Whether it is useful to overcome the hazardous effects of cell phone radiation needs to be clarified. So, this study aimed to investigate the effect of LXRs activation on testicular changes in rats exposed to electromagnetic radiation. Methods: Thirty adult male Wistar rats were subdivided into control group, experimental group: exposed to cell phone electromagnetic radiation, and treated group: as experimental group and received LXRs agonist T0901317. Serum testosterone (T), Follicle-Stimulating Hormone (FSH), and Luteinizing Hormone (LH), testicular tissue malondialdehyde (MDA) and superoxide dismutase (SOD), and gene expressions of inflammatory and apoptotic markers were assessed. Seminal analysis and testicular histological examination were performed. Results: LXRs activation in rats exposed to cell phone radiation improved the decreased testicular and gonadotrophic hormones, semen quality parameters, tissue SOD, and anti-apoptotic gene expression as well as the elevated tissue MDA, apoptotic and inflammatory gene expressions, and the testicular histological changes induced by exposure to electromagnetic radiation. Conclusion: Exposure to cell phone radiation leads to harmful effects on spermatogenesis and LXRs activation could improve these effects via antioxidant, anti-inflammatory properties in addition to its endocrinal action.
Author Related Publications
Randah Salah Gomaa, "تأثيرات اعطاء منشط مستقبل الجهد المؤقت أنكرين-1 علي عدد كرات الدم البيضاء في الفئران. Effects of in vivo administration TRPA1 agonist on leukocytic count in rats", zagazig University, 2010
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Randah Salah Gomaa, "تأثيرات تناول جرعة وحيدة من الكحول علي خلايا الدم في الفئران Effects of single administration of alcohol on hematocytes in rats", zagazig univerisity, 2010
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Randah Salah Gomaa, "تأثير الأبلين على القياسات الجسدية للفئران العادية والبدينة Effect of Apelin on anthropometric measures of normal and obese rats", Al-Azhar univeristy, 2012
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Randah Salah Gomaa, "تأثيرات أليل ايزوثيوسيانات المتوقفة علي الوقت علي بعض مؤشرات الايض في الفئران. Time-Dependent Effect of Allyl Isothiocyanate on Some Metabolic Parameters in Rats", zagazig univerisity, 2011
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Randah Salah Gomaa, "Subacute effects of TRPV1 agonist on energy metabolism in rats التأثيرات تحت الحادة لمنشط مستقبل الجهد المؤقت فانيلويد-1 علي ايض الطاقة في الفئران", zagazig univerisity, 2011
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Department Related Publications
Enas Alsayed Nassar, "A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic andAtherogenic Disorders Related to Obesity in White Albino Rats", The Open Obesity Journal, 2013
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Randah Salah Gomaa, "Subacute effects of TRPV1 agonist on energy metabolism in rats التأثيرات تحت الحادة لمنشط مستقبل الجهد المؤقت فانيلويد-1 علي ايض الطاقة في الفئران", zagazig univerisity, 2011
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Azza Abdelrahman Youssef Megahed, "ROLE OF VISFATIN IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY EXPERIMENTALLY INDUCED IN ADULT MALE ALBINO RATS", جامعـة الزقازيق الطبيــة, 2013
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Nawal Khalil Gerges, "Serum chemerin level in relation to renal function in experimentally induced diabetic rats", Scientific Journal of AL-Azhar Medical Faculty (Boys), 2017
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Doaa Attia Abdelmoeti, "Evaluation of serum irisin and creatine kinase levels in hypo and hyperthyroid rats", Al-Azhar Medical Journal مجلة طب الأزهر(بنين), 2017
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