Schistosomiasis is an endemic parasitic infective disease that remains widespread in several countries. This work aimed to evaluate the curative influence of bone marrow derived mesenchymal stem cells (BM-MSC) engraftment in liver of mice infected with chronic schistosomiasis. 30 Swiss albino mice divided into 3 groups (10 mice each). Group1: normal healthy group. Group2: infected with Schistosoma mansoni cercariae subcutaneously. Group 3: infected and transplanted with BM-MSC on their 8th week post infection by intravenous injection. All mice were sacrificed 4 weeks post-transplantation. Serum was collected for assessment of albumin, ALT and AST levels. Engraftment of BM-MSC was assessed by labelling with PKH26. Histopathological and ultrastructural studies were carried out. Expression of capase-3 and IL-1as a markers of apoptosis and inflammation respectively were measured by quantitative RT-PCR. Homing of transplanted BM-MSC within the injured liver was confirmed by fluorescent microscopic examination. MSC labeled with PKH26 were recovered inside the liver. Histopathological and electron microscopic examinations of the liver showed differentiation of transplanted BM-MSC into hepatocyte-like cells. Liver function was improved confirmed by elevation of serum albumin and decrease of liver enzymes (ALT, AST) in Group 3. Real-time PCR results revealed that BM-MSC inhibited capase-3 and suppressinterleukin-1 mRNA expression in damaged liver tissues. This indicated that MSC-treated group had the least apoptosis cells and inflammatory cells. Transplantation of BM-MSCs have therapeutic anti-apoptotic anti-inflammatory mechanisms effect in chronic liver disease.