Two Factorial field experiments on wheat (Var. Msr2) were conducted during two successive seasons (2015/2016 and 2016/2017).The factors involved gypsum application (none, 100% gypsum requirements) × organic fertilizer rate (none, 20 m3 fed-1) × nitrogen fertilizer rates (none, 100 kg N fed-1) × zinc fertilizer rates (none, 5 kg Zn fed-1) × 4 replicates. The soils of the experimental locations have been clay loam in texture and the mean values of some properties were ECe = 6.40 dS.m-1, ESP = 18.11 % , pH = 8.30 which reveals higher effects with salinity and sodicity. The important results could be summarized as follows: 1- The addition of gypsum according to soil gypsum requirements (GR) prior wheat cultivation resulted in higher wheat yields as a result of its ameliorative role in soil-pH; soil-EC; soil-ESP and subsequently increasing the availability of some nutrients. 2- Better wheat yields have been obtained by adding organic manure of 20 m3 fed-1 compost, as a result of modifying various soil physico-chemicals characteristics and subsequently increasing most nutrients availability. 3- Nitrogen fertilization with the recommended rate of 100 kg N fed-1 (as Ammonium sulfate) led to higher wheat yields as compared to none-fertilized treatment. 4- Zinc sulfate fertilization at rate of 5 kg Zn fed-1 for wheat led to better yields; where that response is related to native Zn- unavailability due to higher values of soil-pH and soil- ESP. 5- The significant interaction of those variables on wheat yield and wheat grains-N and Zn concentrations as well as protein content revealed that their use efficiencies have been affected with each other. The co-additions of (GR) × organic manure × N-fertilizer × Zn fertilizer were highly beneficial in improving N and Zn nutrition for wheat yield in such soils