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Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
95-105
Authors:
Aly Mohamed Abdelrahman Saad
Staff Zu Site
Abstract In Staff Site
Journal:
ESC HEART FAILURE The Heart Failure Association of the European Society of Cardiology
Volume:
8
Keywords :
Differences between familial , sporadic dilated cardiomyopathy:
Abstract:
Abstract Aims Dilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non‐familial (sporadic) DCM (SDCM) across Europe. Methods and results Patients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy & Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P < 0.01), had less severe disease phenotype at presentation (P < 0.02), more favourable baseline cardiovascular risk profiles (P ≤ 0.007), and less medication use (P ≤ 0.042). Outcome at 1 year was similar and predicted by NYHA class (HR 0.45; 95% CI [0.25–0.81]) and LVEF per % decrease (HR 1.05; 95% CI [1.02–1.08]. Throughout Europe, patients with FDCM received more genetic testing (47% vs. 8%, P < 0.01) and had higher genetic yield (55% vs. 22%, P < 0.01). Conclusions We observed that FDCM and SDCM have significant differences at baseline but similar short‐term prognosis. Whether modification of associated cardiovascular risk factors provide opportunities for treatment remains to be investigated. Our results also show a prevalent role of genetics in FDCM and a non‐marginal yield in SDCM although genetic testing is largely neglected in SDCM. Limited genetic testing and heterogeneity in panels provides a scaffold for improvement of guideline adherence.
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Aly Mohamed Abdelrahman Saad, "The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe The Euro Heart Survey on diabetes and the heart", Elsevier, 2004
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Aly Mohamed Abdelrahman Saad, "Treatment and Health Status in Patients with Proven Coronary Artery Disease, but Ineligible for Revascularization. A Report from the Euro Heart Survey on Revascularization", Sage, 2006
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Aly Mohamed Abdelrahman Saad, "Pharmacological treatment and perceived health status during 1-year follow up in patients diagnosed with coronary artery disease, but ineligible for revascularization: Results from the Euro Heart Survey on coronary revascularization", Sage, 2006
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Aly Mohamed Abdelrahman Saad, "A 1-year follow up in patients diagnosed with coronary artery disease, but ineligible for revascularization. Results from The Euro Heart Survey on Coronary Revascularization", Oxford University Press, 2006
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Aly Mohamed Abdelrahman Saad, "Atrial fibrillation management: a prospective survey in ESC Member Countries", Oxford University Press, 2005
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Khaled Mohamed Abdelsalam, "تقييم وظيفة البطين الايسر بعد العلاج الشرايين التاجيةبالقسطرة التداخلية", لايوجد, 1900
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Muntasir Mustafa Ahmad, "هل يوجد دور للاعتلال وظائف البطانة الوعائية في عودة ضيق الشريان", لايوجد, 1900
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