Early predictors of left ventricular dysfunction in hypertensive patients: comparative cross-section study

Faculty Medicine Year: 2020
Type of Publication: ZU Hosted Pages: 1031–1040
Authors:
Journal: The International Journal of Cardiovascular Imaging Springer Nature Switzerland AG. Volume: 36
Keywords : Early predictors , left ventricular dysfunction , hypertensive    
Abstract:
Identifying hypertensive patients who are at higher risk and thus to assess early echocardiographic markers of LV dysfunction in this population. Our comparative cross-section study included 100 patients divided into two groups; Group1: Hypertensive with preserved ejection fraction (EF) (n = 50) & Group 2: Normotensive (Control) (n = 50). Who underwent 2D Echo imaging with analysis of multible parameters of LV systolic and diastolic function including: left atrial volume index (LAVI), LV mass index, relative wall thickness, LV systolic function (EF%), diastolic function (trans-mitral pulsed and tissue Doppler study of E, A, e′-wave velocities& E/A, E/e′ ratios), Global myocardial longitudinal strain (GLS) by speckle tracking echocardiography (STE) and the early diastolic driving force (DF) which calculated as (DF = mass × acceleration; DF = 0.004E2/DT). We reported significant differences between the two groups in LV mass, LA volume and DF, which were all elevated in the hypertensive group, as well as reduced GLS magnitude. We also reported that a GLS cutoff of > − 18.1% was able to accurately “predict subclinical LV systolic dysfunction”. Finally, DF showed a moderate correlation (r = 0.33, which was established with statistical confidence) with E/e′ ratio, and a DF cutoff of ≥ 0.25 N was able to accurately “predict subclinical diastolic dysfunction”. GLS cutoff > − 18.1% could be used for early prediction of LV systolic dysfunction in hypertensive. The early diastolic DF cutoff ≥ 0.25 N could be a useful tool for early prediction of LV diastolic dysfunction in hypertensive. These sensitive parameters could be used for early diagnosis and proper management for better outcomes.
   
     
 
       

Author Related Publications

  • Eslam Alsayed Mohamed Mohamed Shehata, "Resting Left Ventricular Systolic Dyssynchrony and Mechanical Reserve in Asymptomatic Normotensive Subjects with Early Type 2 Diabetes Mellitus", Karger, 2020 More
  • Eslam Alsayed Mohamed Mohamed Shehata, "Mitral annulus time intervals for assessment of left ventricular systolic function in ischemic cardiomyopathy", European Journal of Heart Failure Supplements (2012) 11, S128–S177, 2012 More
  • Eslam Alsayed Mohamed Mohamed Shehata, "Mitral annulus time intervals for assessment of left ventricular systolic function in dilated cardiomyopathy", European Journal of Heart Failure Supplements (2012) 11, S128–S177, 2012 More
  • Eslam Alsayed Mohamed Mohamed Shehata, "Comparison between drug-coated balloon angioplasty and second-generation drugeluting stent placement for the treatment of in-stent restenosis after drug-eluting stent implantation", Springer, 2016 More
  • Eslam Alsayed Mohamed Mohamed Shehata, "Coronary slow flow and its correlation with reduced left ventricle global longitudinal strain: a case–control study", Springer Nature, 2024 More

Department Related Publications

  • Marwa Mohamed Gad Hassan Afifi, "Relationship between aortic distensibility and severity of coronary artery disease", international, 2016 More
  • Eslam Alsayed Mohamed Mohamed Shehata, "Predictive Value of N-Terminal Pro B-Type Natriuretic Peptide for Poor Outcomes in Heart Failure Patients: A Stratified Analysis Based on Ejection Fraction", Springer Nature Link, 2025 More
  • Aly Mohamed Abdelrahman Saad, "Predictive Value of N-Terminal Pro B-Type Natriuretic Peptide for Poor Outcomes in Heart Failure Patients: A Stratified Analysis Based on Ejection Fraction", Springer Nature Link, 2025 More
  • Mohammed Abdel Hadi Mohamed El Sayed, "Predictive Value of N-Terminal Pro B-Type Natriuretic Peptide for Poor Outcomes in Heart Failure Patients: A Stratified Analysis Based on Ejection Fraction", Springer Nature Link, 2025 More
  • Ahmed Shawky Sherif Mahmoud, "Predictive Value of N-Terminal Pro B-Type Natriuretic Peptide for Poor Outcomes in Heart Failure Patients: A Stratified Analysis Based on Ejection Fraction", Springer Nature Link, 2025 More
Tweet