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Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Asra Mohamed Abdelazim Abedallah
Staff Zu Site
Abstract In Staff Site
Journal:
Asian Pacific Journal of Tropical Biomedicine Wolters Kluwer- Medknow
Volume:
Keywords :
Raspberry ketone attenuates high-fat diet-induced obesity
Abstract:
Objective: To investigate the molecular mechanisms of the anti- obese effect of raspberry ketone against high-fat diet fed rats. Methods: Fifty adult male rats were randomly assigned to receive a standard diet, a high fat diet, and the high-fat diet and 0.5%, 1% or 2% raspberry ketone. Body weight, biochemical parameters and gene expression of CCAAT enhancer-binding protein (C/EBP)-δ, fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), peroxisome proliferator-activated receptor alpha (PPAR-α), hormone-sensitive lipase (HSL) and hepatic carnitine palmitoyltransferase 1 A (CPT1A) were investigated. Results: Body weight, blood glucose, insulin, total lipids, triacylglycerols, total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed rats. These high fat diet-induced changes were attenuated by treatment with raspberry ketone. High-density lipoprotein cholesterol was decreased in high- fat diet fed rats but increased in rats treated with raspberry ketone. Molecular investigations showed induction of gene expression of C/EBP-δ, FAS, ACC, CPT1A and inhibition of gene expression of PPAR-α and HSL in high-fat diet fed rats as compared with control. Raspberry ketone treament reversed these changes except CPT1A. Conclusions: Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes, controlling lipolysis and fatty acids β oxidation as well as inhibition of gene expressions of adipogenic factors.
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Asra Mohamed Abdelazim Abedallah, "Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats", Asian Pac J Trop Biomed 2015; 5(10): 832-834., 2015
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