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Safety and Efficacy of 8 Weeks Ledipasvir/Sofosbuvir for Chronic Hepatitis C Genotype 4 in Children Aged 4-10 Years
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ayman Mohamed Abdou
Staff Zu Site
Abstract In Staff Site
Journal:
The Journal of Pediatrics Elsevier
Volume:
Keywords :
Safety , Efficacy , , Weeks Ledipasvir/Sofosbuvir , Chronic Hepatitis
Abstract:
Objective: To evaluate the safety and efficacy of shortened 8-week regimen of ledipasvir/sofosbuvir (LED/SOF) combination therapy in treatment-naïve children without cirrhosis aged 4-10 years of age with chronic hepatitis C virus (HCV) infection. Study design: This observational single arm prospective study included 30 treatment-naïve children (20 males) with proved chronic HCV fulfilling inclusion criteria. Their body weights ranged from 17 to 26 kg. Four patients were excluded from the study. All the included children received a single oral dose of LED/SOF 45/200 mg for 8 weeks. Body weight, HCV-RNA, complete blood count, and liver function tests were monitored at 0, 2, 4, and 8 weeks and sustained virologic response was evaluated after 12 weeks after treatment (SVR12). The emergence of any side effects was also monitored. Results: The most common risk factor (53.3%) was an parent or sibling with HCV infection. Twenty-nine patients (96.7%) were negative for HCV-RNA by week 2 of treatment and 1 patient became negative by week 4. The end of treatment response and SVR12 were 100%. Transaminases levels declined and returned to normal levels by week 2. Major side effects were fatigue in 90% (27/30) and headache in 76.7% (23/30). Side effects were minimal, tolerable, and did not interfere with daily activity or necessitate treatment discontinuation. Conclusions: A shortened 8-week regimen of LED/SOF (45/200 mg) is safe and effective with 100% SVR12 in treatment-naïve children with cirrhosis aged 4-10 years with chronic HCV infection genotype 4.
Author Related Publications
Ayman Mohamed Abdou, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Ayman Mohamed Abdou, "Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review", Taylor and Francis, 2018
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Ayman Mohamed Abdou, "Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts", Mosby Inc, 2019
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Ayman Mohamed Abdou, "Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.", Blackwell Publishing Inc, 2018
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Ayman Mohamed Abdou, "Role of mannose binding lectin in response to candida antigen immunotherapy of warts", talyor &francis, 2019
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "الموت المبرمج للخلية الليمفاويه في مرض الذئبة الحمراء و العلاقة مع دلالة الموت المبرمج(فاس)الذائب في مصل الدم و نشاط المرض", لايوجد, 1900
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Ashwak Mohamed Foad Abotaleb, "العلاقة بين الانتيجينات الانسجه البشرية (الطائفة الاولي 9في مرضى الربو الشعبى)", لايوجد, 1900
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Amal Hassan Mahmoud Atta , "evaluation of the levels of intercellular adhesion molecule -1 and e-selectin in neonatal infection ", لايوجد, 1900
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Ayman Abdelrahman Hussinn, "مدى انتشار فيروس (ت-ت) الكبدى الاطفال و البالغين و مرضى الكبد المصريين", لايوجد, 1900
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Ayman Abdelrahman Hussinn, "الشكل الظاهرى و التركيب الجنسى لبعضهم المعزولات السريرية للبكتيريا السبحية مجموعة (ب)", لايوجد, 1900
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