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Association of TLR2 and TLR4 gene polymorphism with susceptibility to wart infections and their response to candida antigen immunotherapy
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ayman Mohamed Abdou
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Dermatological Treatment Tolyar and Francis
Volume:
Keywords :
Association , TLR2 , TLR4 gene polymorphism with
Abstract:
Background: Warts are prevalent human papilloma virus (HPV) infections which can cause physical and psychological problems. Candida antigen immunotherapy is a safe and promising treatment of warts. Toll-like receptors (TLRs) 2 and 4 gene polymorphisms are implicated in susceptibility and progression of several diseases.Aim: To assess the role of TLR2Arg753GLN and TLR4Asp299Gly polymorphisms in susceptibility to HPV wart infections and their possible effect on response to Candida antigen immunotherapy.Patients and methods: A total of 78 patients and 78 healthy subjects were enrolled in this case control study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect TLR2Arg753GLN and TLR4Asp299Gly genes polymorphisms. Patients' lesions were injected with Candida antigens and the response was assessed.Results: The mutant AA and GG genotypes of TLR2Arg753GLN and TLR4Asp299Gly were significantly detected in patients than controls (p < .001 and p = .01, respectively). Intralesional Candida antigen injections achieved complete and partial clearance in 62.8 and 20.5% of lesions, respectively. No association was found between the studied polymorphisms and response to Candida antigen injections.Conclusions: TLR2Arg753GLN and TLR4Asp299Gly polymorphisms are associated with susceptibility to wart infections, but with no effect on their response to Candida immunotherapy.
Author Related Publications
Ayman Mohamed Abdou, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Ayman Mohamed Abdou, "Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review", Taylor and Francis, 2018
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Ayman Mohamed Abdou, "Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts", Mosby Inc, 2019
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Ayman Mohamed Abdou, "Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.", Blackwell Publishing Inc, 2018
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Ayman Mohamed Abdou, "Role of mannose binding lectin in response to candida antigen immunotherapy of warts", talyor &francis, 2019
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "الموت المبرمج للخلية الليمفاويه في مرض الذئبة الحمراء و العلاقة مع دلالة الموت المبرمج(فاس)الذائب في مصل الدم و نشاط المرض", لايوجد, 1900
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Ashwak Mohamed Foad Abotaleb, "العلاقة بين الانتيجينات الانسجه البشرية (الطائفة الاولي 9في مرضى الربو الشعبى)", لايوجد, 1900
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Amal Hassan Mahmoud Atta , "evaluation of the levels of intercellular adhesion molecule -1 and e-selectin in neonatal infection ", لايوجد, 1900
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Ayman Abdelrahman Hussinn, "مدى انتشار فيروس (ت-ت) الكبدى الاطفال و البالغين و مرضى الكبد المصريين", لايوجد, 1900
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Ayman Abdelrahman Hussinn, "الشكل الظاهرى و التركيب الجنسى لبعضهم المعزولات السريرية للبكتيريا السبحية مجموعة (ب)", لايوجد, 1900
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