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Complement component 3c and tumor necrosis factor-α systemic assessment after Candida antigen immunotherapy in cutaneous warts
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ayman Mohamed Abdou
Staff Zu Site
Abstract In Staff Site
Journal:
Brazilian Journal of Microbiology Springer
Volume:
Keywords :
Complement component , , tumor necrosis factor-α systemic
Abstract:
ackground: Cutaneous warts are the commonest benign lesion produced by human papillomavirus. Lesions often regress spontaneously yet have a high rate of recurrence. They impair patients' quality of life and carry the potential risk of cancer. Nowadays, Candida antigen immunotherapy has become an encouraging therapeutic modality for warts. We tried to assess the role of the complement pathway and T helper 1 immune response in clinical response to Candida antigen immunotherapy via complement component 3c (C3c) and tumor necrosis factor (TNF)-α, respectively. Methods: A total of 44 patients with cutaneous warts were enrolled in the study. Patients were injected with Candida antigen at 2-week interval until complete clearance of the lesion or for a maximum of 5 sessions. Blood samples were collected before initiation and after completion of immunotherapy. C3 and C4 were measured using an automated turbidimetric method. Mannose-binding lectin (MBL), C3c, and TNF-α were measured using enzyme-linked immune sorbent assay. Results: A total of 56.4%, 17.9%, and 25.7% of the patients showed complete, partial, and no response to immunotherapy, respectively. Lesions on the dorsum of the foot and sole showed significant clearance (p value = 0.037). All patients had no deficient C3, C4, and MBL serum levels. C3c and TNF-α serum levels were significantly higher in non-responder group (p value < 0.001 and < 0.001, respectively). C3c and TNF-α serum levels were strongly correlated in all the studied patients (r = 0.8, p value < 0.001).
Author Related Publications
Ayman Mohamed Abdou, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Ayman Mohamed Abdou, "Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review", Taylor and Francis, 2018
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Ayman Mohamed Abdou, "Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts", Mosby Inc, 2019
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Ayman Mohamed Abdou, "Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.", Blackwell Publishing Inc, 2018
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Ayman Mohamed Abdou, "Role of mannose binding lectin in response to candida antigen immunotherapy of warts", talyor &francis, 2019
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "دراسة الاصابة بالميكروبات الحلزونية البوابية في مرضي السكر بالمقارنه بغير المصابين به", لايوجد, 1900
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