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Early intervention with breast milk mesenchymal stem cells attenuates the development of diabetic-induced testicular dysfunction via hypothalamic Kisspeptin/Kiss1r-GnRH/GnIH system in male rats
Faculty
Veterinary Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Tariq Khamis Kamal Ahmed Khamis
Staff Zu Site
Abstract In Staff Site
Journal:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease elsevier
Volume:
Keywords :
Early intervention with breast milk mesenchymal
Abstract:
Diabetic male infertility and sub fertility are major complications that may implicate both central and peripheral pathways as well as mechanisms controlling reproduction. This study was an attempt to explore the potential effect of breast milk mesenchymal stem cells (Br-MSCs) as a therapeutic tool for diabetic induced reproductive dysfunction at molecular level. Forty-five adult male Sprague Dawely rats were divided into 3 groups (n = 15); control group, diabetic group, and Br-MSCs treated diabetic group. The homing ability of Br-MSCs in diabetic treated rat testicles was confirmed via semi-quantitative RT- PCR analysis of a human specific Gapdh mRNA expression level. Our result showed that type1 diabetic rats exerted an elevation in blood glucose level and a reduction in body weight, fasting serum insulin, FSH, LH, and total testosterone levels, relative and absolute testicular weights, sperm count, motility, and live ratio. In addition, downregulation in the hypothalamic kisspeptin-GnRH system, HPG axis and testicular steroidogenesis compared to control group was noticed. Moreover, upregulation of testicular proinflammatory and apoptotic markers relative mRNA expression compared to control group was observed. Furthermore, a decrease in testicular tissue antioxidant activity (CAT, SOD, GSH) and an increase in lipid peroxidation (MDA) compared to control group was shown. However, Br-MSCs administration restored or even exceeded the normal physiological tone in most of these parameters to the point where a potential therapeutic role for Br-MSCs in type1diabetic induced infertility can be suggested.
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Tariq Khamis Kamal Ahmed Khamis, "Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model", elsevier, 2021
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Ahmed Abdoh Said Muhmmd, "Practical Pharmacology and Dispensing, 5th ed", لايوجد, 1900
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