Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti- Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody−Drug Conjugate

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 11135−11144
Authors:
Omnia Ahmed Emam Ismaiel
Journal: Analytical Chemistry American Chemical Society Volume:
Keywords : Multifaceted Bioanalytical Methods , , Comprehensive Pharmacokinetic , Catabolic Assessment    
Abstract:
Herein, we present bioanalytical characterization of the PK and catabolism of a novel ADC. MEDI3726 targets prostate-specific membrane antigen (PMSA) and is comprised of a humanized IgG1 antibody site-specifically conjugated to tesirine (SG
    
     
 
       

Author Related Publications

  • Omnia Ahmed Emam Ismaiel, "Non-extractive spectrophotometric determination of memantine HCl, clomipramine HCl and fluvoxamine maleate in pure form and in pharmaceutical products by ion-pair complex formation with rose Bengal.", ScienceDirect, 2020 More
  • Omnia Ahmed Emam Ismaiel, "Monitoring phospholipids for assessment of matrix effects in a liquid chromatography–tandem mass spectrometry method for hydrocodone and pseudoephedrine in human plasma", USA, 2007 More
  • Omnia Ahmed Emam Ismaiel, "Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations", USA, 2008 More
  • Omnia Ahmed Emam Ismaiel, "Assessment of matrix effects and determination of niacin in human plasma using liquid–liquid extraction and liquid chromatography–tandem mass spectrometry", USA, 2008 More
  • Omnia Ahmed Emam Ismaiel, "Development of a Liquid Chromatography-Negative ESI-Tandem Mass Spectrometry Method for Ibuprofen with Minimization of Matrix Effects Associated with Phospholipids", USA, 2008 More

Department Related Publications

  • Wafaa Wafaa Alsayed Hassan Abdelatef Abolabn, "Conductometric and spectroscopic determination of mebeverine hydrochloride and the solubility products of its ion-recognition species", -, 2013 More
  • Naglaa Abdelsatar Mohamed, "Sustainability assessment of the micellar optimized HPLC method for concomitant quantification of a common triple regimen for cardiovascular disorders: application to marketed formulations and in vitro dissolution testing", The Royal Society of Chemistry, 2025 More
  • Yasmin Ahmed Ibrahim, "Sustainability assessment of the micellar optimized HPLC method for concomitant quantification of a common triple regimen for cardiovascular disorders: application to marketed formulations and in vitro dissolution testing", The Royal Society of Chemistry, 2025 More
  • Hisham Ezzat Abdelattef Ibrahiem, "Sustainability assessment of the micellar optimized HPLC method for concomitant quantification of a common triple regimen for cardiovascular disorders: application to marketed formulations and in vitro dissolution testing", The Royal Society of Chemistry, 2025 More
Tweet