Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Gihad Abousaty Mohamed Ismaeil Mekky
Journal: Scientific Reports Nature Volume:
Keywords : Multicellular , Neurovascular Unit Model , Assessing Hypoxia    
Abstract:
This 3D organoid model recapitulates characteristics of BBB dysfunction under hypoxic physiological conditions and when exposed to exogenous neuroinflammatory mediators and hence may have potential in disease modeling and therapeutic development.
    
     
 
       

Author Related Publications

  • Gihad Abousaty Mohamed Ismaeil Mekky, "hepatoprotective effect of curcumin and vitamin C against cisplatin induced oxidative .stress and toxicity in albino rats", the journal of american science, 2014 More
  • Gihad Abousaty Mohamed Ismaeil Mekky, "Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model", Nature, 2020 More
  • Gihad Abousaty Mohamed Ismaeil Mekky, "The potential toxic effects of magnesium oxide nanoparticles and valproate on liver tissue", Wiley, 2020 More

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