Doxazosin Mesylate (DOX) is an antihypertensive drug which possesses poor water solubility and hence low bioavailability. The study objective is to prepare DOX fast disintegrating tablets as a new dosage form for geriatric patients. First, 23 full factorial design using Polyvinyl pyrrolidone k 30, Poloxamer-407 and Sodium Lauryl Sulphate at low and high ratios were used for preparation of DOX nanosuspension as a trial to improve its dissolution properties. Nanosuspension formulations were characterized using Transmission electron microscopy, Differential scanning calorimetry and Fourier transform infrared spectroscopy. Then, the optimized formula was incorporated in fast disintegrating tablets using different superdisintegrants. The tablets were evaluated for hardness, thickness, friability percentage, diameter, weight variation, Wetting time, disintegration time and percentage dissolution after 10 min. A significant reduction (rapidly and efficiently) in mean arterial pressure of hypertensive rats was observed for DOX nanosuspension fast disintegrating tablet using Ac-Di-Sol as a superdisintegrant with 100% dissolution after 10 min.