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The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-kappaB signaling pathway
Faculty
Pharmacy
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Amro Abdelraof Abdelghany Mahmoud
Staff Zu Site
Abstract In Staff Site
Journal:
Naunyn-Schmiedeberg's Archives of Pharmacology Springer Link
Volume:
Keywords :
, renoprotective effect , glycyrrhizic acid , insulin-resistant rats
Abstract:
Aluminum is well recognized as a nephrotoxic agent. Its hazardous effects arise from the high risk of daily exposure. The consumption of fructose also represents a critical health issue that might negatively impact different organs, including the kidneys. To pursue our previous work, this study aimed to investigate the potential renoprotective effects of glycyrrhizic acid (GLYA) on aluminum-induced nephrotoxicity in insulin-resistant rats. Insulin resistance (IR) was induced by adding fructose (10%) in drinking water for 18 weeks. Male Wistar rats were divided into five groups: control (CTRL), aluminum chloride (ALM, 34 mg/kg/day), fructose (FRCT), aluminum plus fructose (AL/FR), and GLYA (rats received AL/FR and treated with 40 mg/kg GLYA daily). AL/FR resulted in abnormal renal function tests and renal tissue injury. This was associated with increased oxidative stress and inflammation in the renal tissue. Moreover, the expressions of the toll-like receptor 4 (TLR4) and its adaptor proteins were increased in AL/FR group. The administration of GLYA mollified AL/FR-induced renal injury, oxidative stress, activation of the TLR4 signaling pathway, and inflammation. In conclusion, we provide evidence for the promising renoprotective effect of GLYA against AL/FR-induced kidney damage in rats. The renoprotection is attributed to the suppression of oxidative stress and inhibition of the TLR4/NF-kappaB signaling pathway in the kidneys.
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Amro Abdelraof Abdelghany Mahmoud, "Antifibrotic activity of hesperidin against dimethylnitrosamineinduced liver fibrosis in rats", Springer, 2014
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Amro Abdelraof Abdelghany Mahmoud, "Ursodeoxycholic Acid Ameliorates Fructose-Induced Metabolic Syndrome in Rats", PLOS One, 2014
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Department Related Publications
Hassan Mahmoud Mohamed Elfayomy, "Pharmacological Studies on the Possible Interaction between some psychotropics& ", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "A comparative study of centrally and peripherally administered", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "The modulatory effect of antidiabetic drugs on thyroid function in diabetic", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "Does vitamin B]&6 modulate the hypolipidemic effect of complamin,", لايوجد, 1900
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Mohammed Nagieb Mohamed Zakarya Hassan , "Evidence that free radicals may contribute to the development of rinduced arrhythmias in the isolated rat heart", لايوجد, 1900
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