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The Effect of Bovine Viral Diarrhea Virus (BVDV) Strains and the Corresponding Infected-Macrophages’ Supernatant on Macrophage Inflammatory Function and Lymphocyte Apoptosis
Faculty
Veterinary Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Hossam Mohamed Abdallah Muhamed
Staff Zu Site
Abstract In Staff Site
Journal:
VIRUSES MDPI
Volume:
Keywords :
, Effect , Bovine Viral Diarrhea Virus (BVDV) Strains
Abstract:
Bovine viral diarrhea virus (BVDV) is an important viral disease of cattle that causes immune dysfunction. Macrophages are the key cells for the initiation of the innate immunity and play an important role in viral pathogenesis. In this in vitro study, we studied the effect of the supernatant of BVDV-infected macrophage on immune dysfunction. We infected bovine monocyte-derived macrophages (MDM) with high or low virulence strains of BVDV. The supernatant recovered from BVDV-infected MDM was used to examine the functional activity and surface marker expression of normal macrophages as well as lymphocyte apoptosis. Supernatants from the highly virulent 1373-infected MDM reduced phagocytosis, bactericidal activity and downregulated MHC II and CD14 expression of macrophages. Supernatants from 1373-infected MDM induced apoptosis in MDBK cells, lymphocytes or BL-3 cells. By protein electrophoresis, several protein bands were unique for high-virulence, 1373-infected MDM supernatant. There was no significant difference in the apoptosis-related cytokine mRNA (IL-1beta, IL-6 and TNF-a) of infected MDM. These data suggest that BVDV has an indirect negative effect on macrophage functions that is strain-specific. Further studies are required to determine the identity and mechanism of action of these virulence factors present in the supernatant of the infected macrophages
Author Related Publications
Hossam Mohamed Abdallah Muhamed, "Virulotyping and genetic diversity of Aeromonas hydrophila isolated from Nile tilapia (Oreochromis niloticus) in aquaculture farms in Egypt", Elsevier, 2021
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Hossam Mohamed Abdallah Muhamed, "Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae Isolated from Egyptian Patients with Suspected Blood Stream Infection", plos one, 2015
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Hossam Mohamed Abdallah Muhamed, "Effect of cereal type and plant extract addition on the growth performance, intestinal morphology, caecal microflora, and gut barriers gene expression of broiler chickens", ELSEVIER, 2021
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Hossam Mohamed Abdallah Muhamed, "Extended-Spectrum β-Lactamases and/or Carbapenemases-Producing Enterobacteriaceae Isolated from Retail Chicken Meat in Zagazig, Egypt", Plos one, 2015
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Hossam Mohamed Abdallah Muhamed, "Fecal carriage of extended-spectrum β-lactamase- and carbapenemase-producing Enterobacteriaceae in Egyptian patients with community-onset gastrointestinal complaints: a hospital -based cross-sectional study", biomedcentral, 2017
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Department Related Publications
Ahlaam Abd Al Aziz Gharieb Ibrahim, "Association of Plasmid-Mediated Quinolone Resistance with AmpC- Beta-Lactamase Producing E. coli strains from Different Sources", Zagazig Univerisity, 2014
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Iman Ibrahim Attia Sweilem, "The presence of toxin genes of Clostridium perfringens isolated from camels and humans in Egypt. تواجد جينات السموم في المطثية الحاطمة المعزولة من الإبل والآدميين بمصر", كلية الطب البيطرى كرواتيا, 2010
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Iman Ibrahim Attia Sweilem, "Isolation of Staphylococcus aureus from milk and human with reference to its survival on surfaces. عزل المكور العنقودى الذهبى من الحليب والآدميين مع الإشارة لبقائها على الأسطح.", كلية الطب البيطرى - جامعة الزقازيق, 2013
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Lamia Mohammad Reza Mohammad Noman, "Studies on Antibiotic Resistance of Escherichia coli isolated from poultry and children", Sues Canal Vet. Med. J, accepted for publication (2013), 2013
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Lamia Mohammad Reza Mohammad Noman, "Bacteriological studies of Salmonella typhimurium isolated from cow calves and lambs", Assiut Vet. Med. J. Vol. 60 No. 140 January 2014, 2014
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