High densities of the glassy clover snails (Monacha cartusiana) were recorded at the last few years in large number of villages at Sharkia Governorate, Egypt. The present study designed to control this agricultural destructive pest using ethanolic extract of the Ice plant (Mesembryanthmum crystalinum) using poisonous baits technique. Toxicological tests showed that 20% of extract caused 40% mortality of clover snails while 30% extract caused 70% mortality and the highest mortality percentage (90%) was recorded after treatment with 40% extract for 28 days. Enzymatic estimations showed that treatment with LC25 extract caused an elevation in ALT, AST, ACP, ALP, α esterase and phenoloxidase levels of treated snails while levels of amylase, protease and β-esterase were decreased compared to control snails. Histological investigation of the digestive gland of snails exposed to LC25 of M. crystalinum extract revealed that the digestive tubules suffered from severe cellular destructions, inflammatory infiltrate and vacoulations. In addition, sections through the ovotestis showed deformations of oocytes.