Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal
Faculty
Pharmacy
Year:
2013
Type of Publication:
Article
Pages:
Authors:
Hassan, Wafaa S, Sayed, Rania A, El-Mammli, Magda Y, Shalaby, Abadalla
DOI:
10.1155/2013/214270
Journal:
JOURNAL OF SPECTROSCOPY HINDAWI PUBLISHING CORPORATION
Volume:
Research Area:
Biochemistry \& Molecular Biology; Spectroscopy
ISSN
ISI:000314423800001
Keywords :
, Spectrophotometric , Conductometric Methods , Macrolide Antibiotics Determination
Abstract:
Two Simple, accurate, precise, and rapid spectrophotometric and conductometric methods were developed for the estimation of erythromycin thiocyanate (I), clarithromycin (II), and azithromycin dihydrate (III) in both pure and pharmaceutical dosage forms.. e spectrophotometric procedure depends on the reaction of rose bengal and copper with the cited drugs to form stable ternary complexes which are extractable with methylene chloride, and the absorbances were measured at 558, 557, and 560 nm for (I), (II), and (III), respectively.. e conductometric method depends on the formation of an ion-pair complex between the studied drug and rose bengal. For the spectrophotometric method, Beer's law was obeyed.The correlation coefficient (r(2)) for the studied drugs was found to be 0.9999. The molar absorptivity (epsilon.), Sandell's sensitivity, limit of detection (L D), and limit of quantification (L) were also calculated.. e proposed methods were successfully applied for the determination of certain pharmaceutical dosage forms containing the studied drugs
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف