Severe infestations of isopods on some economic fishes inhabiting Qarun Lake were observed during April 2020. The present light and Scanning electron microscopic studies have been carried out on gravid female Anilocra sp. parasitizing Tilapia zillii collected from this Lake. A stereomicroscopic study has been carried out to illustrate the morphological characteristics of this cymothoid isopod. Detailed Scanning electron microscopic investigations were achieved on surface ultrastructural modifications of ovigerous females such as cephalic sensory organs, piercing-sucking mouthparts, pereopods, pleopods, and different developmental stages of ova within the marsupium. Further molecular, taxonomic, and ultrastructural studies must be done to provide profitable knowledge helping in the identification of these deleterious isopods devouring economic fishes of Qarun Lake.