High population densities of Monacha cartusiana were observed to cause perdition of various economic crops at Sharkia Governorate. The present study was carried out control this harmful pest using ethanolic Ginger extract as a natural and environmentally safe molluscicide. Toxicological tests revealed that low concentration (20%) of ethanolic Ginger extract caused 10 % mortality of clovers nails after one day of exposure and 66.7% mortality after 28 days. The highest mortality percentage (90 %) was recorded after 28 days of treatment with 40% Ginger extract. Biochemical investigations showed that LC25 (7.04%) Ginger extract elevated ALT, AST, α & β esterases and phenoloxidase levels of treated snails compared to control. Histological inspections of the digestive gland and ovotestis of snails exposed to LC25 Ginger extract revealed that the digestive tubules showed various tubular anomalies, inflammatory hemocytes infiltration, excessive luminal secretions and appearance of necrotic areas. Acini of ovotestis were deformed and comprised misshapen eggs and distorted sperms. TEM investigations showed cellular malformations in the digestive gland of treated snails including; severely disrupted microvilli, ruptured cell membranes, fractured RER and mitochondrial pyknosis.